iPTMnet Report for Q5ST30 (VARS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5ST30 / SYVM_HUMAN
Protein Name Valine--tRNA ligase, mitochondrial precursor
Gene Name Name: VARS2
Synonyms:KIAA1885,VARS2L,VARSL;
Organism Homo sapiens (Human)

PRO ID PR:Q5ST30
DAG View
PRO Name valine--tRNA ligase, mitochondrial (human)
Definition A valine--tRNA ligase, mitochondrial that is encoded in the genome of human.
Short Label hVARS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5ST30 (VARS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K54 Ubiquitination PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S1039 Phosphorylation PhosphoSitePlus
K1043 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S288 L288 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S662 F662 Biomuta DOID:4159 / skin cancer [ cosmic ]
S776 F776 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]