Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5SSJ5 / HP1B3_HUMAN
Protein Name Heterochromatin protein 1-binding protein 3
Gene Name Name: HP1BP3
Organism Homo sapiens (Human)

PRO ID PR:Q5SSJ5
DAG View
PRO Name heterochromatin protein 1-binding protein 3 (human)
Definition A heterochromatin protein 1-binding protein 3 that is encoded in the genome of human.
Short Label hHP1BP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5SSJ5 (HP1BP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 20068231
T3 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K14 Ubiquitination PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
T51 Phosphorylation PhosphoSitePlus   UniProt 23186163
S70 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus   UniProt 17525332, 20068231
R146 Methylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S156 Phosphorylation PhosphoSitePlus   UniProt 20068231
K160 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K190 Acetylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
S249 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K258 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus   UniProt 21406692
S442 Phosphorylation PhosphoSitePlus   UniProt 21406692
S446 Phosphorylation PhosphoSitePlus   UniProt 21406692
T461 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
T529 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
T544 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 19691289
S6 Phosphorylation HPRD 20068231
S47 Phosphorylation HPRD 19691289
T48 Phosphorylation HPRD 19691289
T51 Phosphorylation HPRD 19651622, 19691289, 20068231, ...18452278
S70 Phosphorylation HPRD 20058876, 18452278
S71 Phosphorylation HPRD 18452278
S74 Phosphorylation HPRD 18452278
S76 Phosphorylation HPRD 18452278
T77 Phosphorylation HPRD 18452278
T85 Phosphorylation HPRD 20068231, 18452278
T132 Phosphorylation HPRD 17693683
S142 Phosphorylation HPRD 17525332, 20068231, 17693683
S155 Phosphorylation HPRD 20068231
S156 Phosphorylation HPRD 17081983, 20068231, 19691289
S176 Phosphorylation HPRD 19691289
S248 Phosphorylation HPRD 19651622, 18669648, 19691289, ...20068231
S249 Phosphorylation HPRD 18669648, 19691289, 20068231
S441 Phosphorylation HPRD 17287340, 18452278
S442 Phosphorylation HPRD 17287340, 18452278
S446 Phosphorylation HPRD 17287340, 18452278
T461 Phosphorylation HPRD 20068231
S465 Phosphorylation HPRD 20068231
S548 Phosphorylation HPRD 20068230


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ]
T51 I51 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S71 L71 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T77 I77 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S91 I91 Biomuta DOID:2394 / ovarian cancer [ tcga ]
Y284 D284 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K291 R291 Biomuta DOID:1909 / melanoma [ cosmic ]
K320 R320 Biomuta DOID:1612 / breast cancer [ tcga ]
S377 Y377 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S442 L442 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K508 M508 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S524 L524 Biomuta DOID:1324 / lung cancer [ tcga ]
T529 A529 Biomuta DOID:10534 / stomach cancer [ cosmic ]