iPTMnet Report for Q5SRI9 (MANEA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5SRI9 / MANEA_HUMAN
Protein Name Glycoprotein endo-alpha-1,2-mannosidase
Gene Name Name: MANEA
Organism Homo sapiens (Human)

PRO ID PR:Q5SRI9
DAG View
PRO Name glycoprotein endo-alpha-1,2-mannosidase (human)
Definition A glycoprotein endo-alpha-1,2-mannosidase that is encoded in the genome of human.
Short Label hMANEA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5SRI9 (MANEA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
T73 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S78 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T82 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S86 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
Y321 Phosphorylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
Y424 Phosphorylation PhosphoSitePlus
Y427 Phosphorylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
T452 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T73 I73 Biomuta DOID:363 / uterine cancer [ icgc ]
S78 I78 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y323 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y331 C331 Biomuta DOID:1612 / breast cancer [ cosmic ]
S447 I447 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y453 C453 Biomuta DOID:2531 / hematologic cancer [ cosmic ]