iPTMnet Report for Q5QNW6 (H2BC18)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5QNW6 / H2B2F_HUMAN
Protein Name Histone H2B type 2-F
Gene Name Name: H2BC18
Synonyms:HIST2H2BF;
Organism Homo sapiens (Human)

PRO ID PR:Q5QNW6
DAG View
PRO Name histone H2B type 2-F (human)
Definition A histone H2B type 2-F that is encoded in the genome of human.
Short Label hH2BC18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5QNW6 (H2BC18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
K6 Acetylation PRO   UniProt 18552846, 16283522
K12 Acetylation PhosphoSitePlus
K13 Acetylation PRO   UniProt 18552846, 20693536, 16283522
S15 Phosphorylation PRO   UniProt 12757711
K16 Acetylation PRO   PhosphoSitePlus   UniProt 19608861, 19883641, 16283522
K17 Acetylation PRO   UniProt 19608861, 20693536
K21 Acetylation PRO   UniProt 18552846, 19608861, 16283522
K24 Acetylation PhosphoSitePlus
K35 Ubiquitination UniProt 21726816
K47 Acetylation PRO 20693536
S56 Phosphorylation PhosphoSitePlus
K121 Acetylation PRO 18552846
K121 Ubiquitination PRO   UniProt 18400894, 16307923, 19575011, ...16713563, 18923072, 18832071


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045145 (hHIST2H2BF/InitMet-/Ac:1) acK13 PRO 16283522, 18552846, 20693536
PR:000045146 (hHIST2H2BF/InitMet-/Phos:1) pS15 PRO 12757711
PR:000045147 (hHIST2H2BF/InitMet-/Ac:2) acK21 PRO 16283522, 18552846
PR:000045149 (hHIST2H2BF/InitMet-/Ubiq:1) ubK121 PRO 16307923, 16713563, 18400894, ...18832071, 18923072, 19575011
PR:000045150 (hHIST2H2BF/InitMet-/Ac:3) acK17 PRO 20693536
PR:000045151 (hHIST2H2BF/InitMet-/Ac:4) acK6 PRO 18552846
PR:000045153 (hHIST2H2BF/InitMet-/Ac:5) acK47 PRO 20693536
PR:000045154 (hHIST2H2BF/InitMet-/Ac:6) acK121 PRO 18552846
PR:000045155 (hHIST2H2BF/InitMet-/Ac:7) acK16 PRO 19883641
PR:000047855 (hHIST2H2BF/InitMet-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K12 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K13 R13 Biomuta DOID:3571 / liver cancer [ cosmic ]
S15 P15 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S15 F15 Biomuta DOID:263 / kidney cancer [ cosmic ]
K17 N17 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K35 R35 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S56 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]