iPTMnet Report for Q5M775 (SPECC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5M775 / CYTSB_HUMAN
Protein Name Cytospin-B
Gene Name Name: SPECC1
Synonyms:CYTSB,NSP5;
Organism Homo sapiens (Human)

PRO ID PR:Q5M775
DAG View
PRO Name cytospin-B (human)
Definition A cytospin-B that is encoded in the genome of human.
Short Label hSPECC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5M775 (SPECC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R2 Myristoylation UniProt 25807930
S34 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus   RLIMS-P 23970830
S38 Phosphorylation PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus   UniProt 23186163
T76 Phosphorylation PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus   UniProt 23186163
S88 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus   UniProt 23186163
S120 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S131 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S133 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S134 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T136 Phosphorylation PhosphoSitePlus
S137 Phosphorylation phospho.ELM 18669648
S138 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T140 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T142 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T144 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
T215 Phosphorylation PhosphoSitePlus
S218 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T222 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K302 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S323 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S325 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T338 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
S361 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S364 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S366 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
S425 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S437 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
C540 Methylation IEDB 31844290
K591 Ubiquitination PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
Y626 Phosphorylation PhosphoSitePlus
Y628 Phosphorylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
S654 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K679 Ubiquitination PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
T718 O-Glycosylation GlyGen 30379171, 28510447
K739 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
T809 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S810 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T812 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
T844 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S847 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
S850 Phosphorylation PhosphoSitePlus
S863 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y871 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
K897 Ubiquitination PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
S912 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S914 Phosphorylation PhosphoSitePlus   UniProt 23186163
S917 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus
S935 Phosphorylation PhosphoSitePlus
K940 Ubiquitination PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
S946 Phosphorylation PhosphoSitePlus
K950 Ubiquitination PhosphoSitePlus
K964 Acetylation PhosphoSitePlus
K970 Acetylation PhosphoSitePlus
C972 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S131 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18212344
S133 Phosphorylation HPRD 18669648, 19664995
S134 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995
T136 Phosphorylation HPRD 19413330
S137 Phosphorylation HPRD 18669648
S138 Phosphorylation HPRD 18669648
T140 Phosphorylation HPRD 19413330, 18669648
T142 Phosphorylation HPRD 19413330, 18669648
T149 Phosphorylation HPRD 20068231
S189 Phosphorylation HPRD 20068231
S218 Phosphorylation HPRD 18669648, 20068231
S241 Phosphorylation HPRD 20068231
T311 Phosphorylation HPRD 17081983
S312 Phosphorylation HPRD 17081983
S314 Phosphorylation HPRD 17081983
S315 Phosphorylation HPRD 17081983, 20068231
S316 Phosphorylation HPRD 17081983
S317 Phosphorylation HPRD 17081983, 20068231
T320 Phosphorylation HPRD 17081983
S329 Phosphorylation HPRD 17081983
T335 Phosphorylation HPRD 17081983
T338 Phosphorylation HPRD 17081983
S340 Phosphorylation HPRD 17081983
S344 Phosphorylation HPRD 20068231
S356 Phosphorylation HPRD 20068231
T357 Phosphorylation HPRD 20068231
S360 Phosphorylation HPRD 19413330, 17081983
S361 Phosphorylation HPRD 18669648, 17081983, 20068231
S364 Phosphorylation HPRD 18669648, 17081983, 20068231
S366 Phosphorylation HPRD 17081983
S425 Phosphorylation HPRD 19651622, 18669648, 20068231
S654 Phosphorylation HPRD 18669648
T809 Phosphorylation HPRD 18669648, 19664995, 20068231
S810 Phosphorylation HPRD 19413330, 18669648, 18491316, ...19664995
S826 Phosphorylation HPRD 20068231
T844 Phosphorylation HPRD 18669648
S847 Phosphorylation HPRD 18669648, 19664994, 20068231
S863 Phosphorylation HPRD 18669648, 19664995, 20068231
S912 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S131 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18212344
S133 Phosphorylation HPRD 18669648, 19664995
S134 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995
T136 Phosphorylation HPRD 19413330
S137 Phosphorylation HPRD 18669648
S138 Phosphorylation HPRD 18669648
T140 Phosphorylation HPRD 19413330, 18669648
T142 Phosphorylation HPRD 19413330, 18669648
T149 Phosphorylation HPRD 20068231
S189 Phosphorylation HPRD 20068231
S218 Phosphorylation HPRD 18669648, 20068231
S241 Phosphorylation HPRD 20068231
T311 Phosphorylation HPRD 17081983
S312 Phosphorylation HPRD 17081983
S314 Phosphorylation HPRD 17081983
S315 Phosphorylation HPRD 17081983, 20068231
S316 Phosphorylation HPRD 17081983
S317 Phosphorylation HPRD 17081983, 20068231
T320 Phosphorylation HPRD 17081983
S329 Phosphorylation HPRD 17081983
T335 Phosphorylation HPRD 17081983
T338 Phosphorylation HPRD 17081983
S340 Phosphorylation HPRD 17081983
S344 Phosphorylation HPRD 20068231
S356 Phosphorylation HPRD 20068231
T357 Phosphorylation HPRD 20068231
S360 Phosphorylation HPRD 19413330, 17081983
S361 Phosphorylation HPRD 18669648, 17081983, 20068231
S364 Phosphorylation HPRD 18669648, 17081983, 20068231
S366 Phosphorylation HPRD 17081983
S425 Phosphorylation HPRD 19651622, 18669648, 20068231
S654 Phosphorylation HPRD 18669648
S790 Phosphorylation HPRD   PhosphoSitePlus 20068231
Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18212344
S52 Phosphorylation HPRD 18669648, 19664995
S53 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995
T55 Phosphorylation HPRD 19413330
S56 Phosphorylation HPRD 18669648
S57 Phosphorylation HPRD 18669648
T59 Phosphorylation HPRD 19413330, 18669648
T61 Phosphorylation HPRD 19413330, 18669648
T68 Phosphorylation HPRD 20068231
S108 Phosphorylation HPRD 20068231
S137 Phosphorylation HPRD 18669648, 20068231
S160 Phosphorylation HPRD 20068231
T230 Phosphorylation HPRD 17081983
S231 Phosphorylation HPRD 17081983
S233 Phosphorylation HPRD 17081983
S234 Phosphorylation HPRD 17081983, 20068231
S235 Phosphorylation HPRD 17081983
S236 Phosphorylation HPRD 17081983, 20068231
T239 Phosphorylation HPRD 17081983
S248 Phosphorylation HPRD 17081983
T254 Phosphorylation HPRD 17081983
T257 Phosphorylation HPRD 17081983
S259 Phosphorylation HPRD 17081983
S263 Phosphorylation HPRD 20068231
S275 Phosphorylation HPRD 20068231
T276 Phosphorylation HPRD 20068231
S279 Phosphorylation HPRD 19413330, 17081983
S280 Phosphorylation HPRD 18669648, 17081983, 20068231
S283 Phosphorylation HPRD 18669648, 17081983, 20068231
S285 Phosphorylation HPRD 17081983
S344 Phosphorylation HPRD 19651622, 18669648, 20068231
S573 Phosphorylation HPRD 18669648
S709 Phosphorylation HPRD   PhosphoSitePlus 20068231
Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation HPRD 19413330, 19651622, 18669648, ...18212344
S52 Phosphorylation HPRD 18669648, 19664995
S53 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995
T55 Phosphorylation HPRD 19413330
S56 Phosphorylation HPRD 18669648
S57 Phosphorylation HPRD 18669648
T59 Phosphorylation HPRD 19413330, 18669648
T61 Phosphorylation HPRD 19413330, 18669648
T68 Phosphorylation HPRD 20068231
S108 Phosphorylation HPRD 20068231
S137 Phosphorylation HPRD 18669648, 20068231
S160 Phosphorylation HPRD 20068231
T230 Phosphorylation HPRD 17081983
S231 Phosphorylation HPRD 17081983
S233 Phosphorylation HPRD 17081983
S234 Phosphorylation HPRD 17081983, 20068231
S235 Phosphorylation HPRD 17081983
S236 Phosphorylation HPRD 17081983, 20068231
T239 Phosphorylation HPRD 17081983
S248 Phosphorylation HPRD 17081983
T254 Phosphorylation HPRD 17081983
T257 Phosphorylation HPRD 17081983
S259 Phosphorylation HPRD 17081983
S263 Phosphorylation HPRD 20068231
S275 Phosphorylation HPRD 20068231
T276 Phosphorylation HPRD 20068231
S279 Phosphorylation HPRD 19413330, 17081983
S280 Phosphorylation HPRD 18669648, 17081983, 20068231
S283 Phosphorylation HPRD 18669648, 17081983, 20068231
S285 Phosphorylation HPRD 17081983
S344 Phosphorylation HPRD 19651622, 18669648, 20068231
S573 Phosphorylation HPRD 18669648
T728 Phosphorylation HPRD 18669648, 19664995, 20068231
S729 Phosphorylation HPRD 19413330, 18669648, 18491316, ...19664995
S745 Phosphorylation HPRD 20068231
T763 Phosphorylation HPRD 18669648
S766 Phosphorylation HPRD 18669648, 19664994, 20068231
S782 Phosphorylation HPRD 18669648, 19664995, 20068231
S831 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R2 W2 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R2 Q2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S50 L50 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S55 N55 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T55 A55 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S131 L131 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T136 A136 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T144 M144 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
T144 R144 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S160 C160 Biomuta DOID:1324 / lung cancer [ cosmic ]
S231 P231 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S233 F233 Biomuta DOID:4159 / skin cancer [ cosmic ]
S234 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S241 C241 Biomuta DOID:1324 / lung cancer [ cosmic ]
S279 N279 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S312 P312 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S314 F314 Biomuta DOID:4159 / skin cancer [ cosmic ]
S315 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S325 L325 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K351 R351 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S360 N360 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K442 R442 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K452 Q452 Biomuta DOID:363 / uterine cancer [ icgc ]
K462 N462 Biomuta DOID:363 / uterine cancer [ icgc ]
K462 Q462 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K462 T462 Biomuta DOID:363 / uterine cancer [ icgc ]
K469 T469 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K535 T535 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T728 I728 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S729 Y729 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T809 I809 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S810 Y810 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S919 R919 Biomuta DOID:263 / kidney cancer [ cosmic ]
S935 F935 Biomuta DOID:4159 / skin cancer [ cosmic ]
S943 N943 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K970 I970 Biomuta [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]