iPTMnet Report for Q5JWF2 (GNAS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5JWF2 / GNAS1_HUMAN
Protein Name Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Gene Name Name: GNAS
Synonyms:GNAS1;
Organism Homo sapiens (Human)

PRO ID PR:Q5JWF2
DAG View
PRO Name guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-1/XLas-2/XLas-3 (human)
Definition A guanine nucleotide-binding protein G(s) subunit alpha (human), isoforms XLas-1, XLas-2, and XLas-3.
Short Label hGNAS/iso:[XLas-1/XLas-2/XLas-3]
Category organism-seqgroup

Interactive Sequence View

Select/align proteoforms across species


Q5JWF2 (GNAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S327 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
C805 Methylation IEDB 31844290
T993 Phosphorylation PhosphoSitePlus
S995 Phosphorylation UniProt 20068231
Site PTM Type PTM Enzyme Score Source PMID
S992 Phosphorylation HPRD 20068231
S995 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S327 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S327 N327 Biomuta DOID:4159 / skin cancer [ cosmic ]
S327 I327 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S532 R532 Biomuta DOID:4159 / skin cancer [ cosmic ]
S625 G625 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y680 C680 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K701 E701 Biomuta DOID:1324 / lung cancer [ cosmic ]
K701 Q701 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
K717 E717 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
C805 F805 Biomuta DOID:3571 / liver cancer [ cosmic ]
C805 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T993 I993 Biomuta DOID:4159 / skin cancer [ cosmic ]
S995 I995 Biomuta DOID:4159 / skin cancer [ cosmic ]
S995 R995 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc, cosmic ]