iPTMnet Report for Q5JU85 (IQSEC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5JU85 / IQEC2_HUMAN
Protein Name IQ motif and SEC7 domain-containing protein 2
Gene Name Name: IQSEC2
Synonyms:KIAA0522;
Organism Homo sapiens (Human)

PRO ID PR:Q5JU85
DAG View
PRO Name IQ motif and SEC7 domain-containing protein 2 (human)
Definition An IQ motif and SEC7 domain-containing protein 2 that is encoded in the genome of human.
Short Label hIQSEC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5JU85 (IQSEC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
R207 Methylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus   UniProt 23186163
S347 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
Y397 Phosphorylation PhosphoSitePlus
K409 Acetylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus   UniProt 23186163
S435 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
T631 Phosphorylation PhosphoSitePlus
K633 Methylation PhosphoSitePlus
T738 Phosphorylation PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
K907 Acetylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1123 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
T1128 Phosphorylation PhosphoSitePlus
Y1129 Phosphorylation PhosphoSitePlus
S1141 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1148 Phosphorylation PhosphoSitePlus
K1152 Ubiquitination PhosphoSitePlus
S1158 Phosphorylation PhosphoSitePlus
S1456 Phosphorylation PhosphoSitePlus
K1478 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S918 Phosphorylation HPRD 18452278
Y924 Phosphorylation HPRD 18452278
S938 Phosphorylation HPRD   PhosphoSitePlus 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S105 I105 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R207 C207 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S344 F344 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S412 L412 Biomuta DOID:1612 / breast cancer [ cosmic ]
S435 F435 Biomuta DOID:4159 / skin cancer [ cosmic ]
S741 I741 Biomuta DOID:363 / uterine cancer [ cosmic ]
S744 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S938 F938 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1141 N1141 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1143 F1143 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1152 R1152 Biomuta DOID:363 / uterine cancer [ cosmic ]
S1456 P1456 Biomuta DOID:4159 / skin cancer [ cosmic ]