iPTMnet Report for Q5JTD0 (TJAP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5JTD0 / TJAP1_HUMAN
Protein Name Tight junction-associated protein 1
Gene Name Name: TJAP1
Synonyms:PILT;
Organism Homo sapiens (Human)

PRO ID PR:Q5JTD0
DAG View
PRO Name tight junction-associated protein 1 (human)
Definition A tight junction-associated protein 1 that is encoded in the genome of human.
Short Label hTJAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5JTD0 (TJAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 22814378
S3 Phosphorylation PhosphoSitePlus
Y11 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
C76 Methylation IEDB 31844290
K155 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
T229 Phosphorylation IEDB 34171305
S300 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 15302935, ...18669648, 24275569, 23186163, 19690332, 20068231
Y316 Phosphorylation PhosphoSitePlus
T318 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S320 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y326 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S345 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
C350 S-Nitrosylation dbSNO 26338901
T351 Phosphorylation PhosphoSitePlus
Y352 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T354 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
T422 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S449 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231, 24275569
R504 Methylation PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
S545 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
T547 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K121 Ubiquitination PhosphoSitePlus
T147 Phosphorylation HPRD 18767875
S198 Phosphorylation HPRD 20068231
S290 Phosphorylation HPRD 20058876, 20230923, 18767875, ...19664994, 19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 20068231
T308 Phosphorylation HPRD 19651622, 18669648, 20068231
S310 Phosphorylation HPRD 19651622, 18669648, 20068231
Y316 Phosphorylation HPRD 20068231
S335 Phosphorylation HPRD 18669648, 20068231
T412 Phosphorylation HPRD 18669648
S481 Phosphorylation HPRD 19664994, 20068231
S535 Phosphorylation HPRD 19413330, 17322306, 18212344, ...18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 20068231
T537 Phosphorylation HPRD 18767875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 N3 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S3 G3 Biomuta DOID:4159 / skin cancer [ cosmic ]
S28 F28 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T37 P37 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K160 M160 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T229 S229 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T354 S354 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
S361 I361 Biomuta DOID:1324 / lung cancer [ icgc ]
R504 M504 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R504 W504 Biomuta [ cosmic ]
S535 R535 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S545 R545 Biomuta DOID:4606 / bile duct cancer [ cosmic ]