iPTMnet Report for Q5JTC6 (AMER1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5JTC6 / AMER1_HUMAN
Protein Name APC membrane recruitment protein 1
Gene Name Name: AMER1
Synonyms:FAM123B,WTX;
Organism Homo sapiens (Human)

PRO ID PR:Q5JTC6
DAG View
PRO Name APC membrane recruitment protein 1 (human)
Definition An APC membrane recruitment protein 1 that is encoded in the genome of human.
Short Label hAMER1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5JTC6 (AMER1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T41 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
T242 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S246 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T250 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus   RLIMS-P 22215675
S318 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
T615 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
Y854 Phosphorylation PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
S895 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
R1091 Methylation PhosphoSitePlus
S1125 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
T1127 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S161 Phosphorylation HPRD 18452278
T242 Phosphorylation HPRD 19413330, 18669648
S246 Phosphorylation HPRD 19413330, 18669648
T250 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S240 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
Y526 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
T803 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q5JTC6 (AMER1) S286 Q14145 (KEAP1) unknown eFIP 22215675


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K195 N195 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S240 F240 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T242 S242 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S246 Y246 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S246 F246 Biomuta DOID:363 / uterine cancer [ cosmic ]
S267 L267 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S280 R280 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S286 R286 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T615 I615 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T615 N615 Biomuta DOID:10534 / stomach cancer [ cosmic ]