iPTMnet Report for Q5JSL3 (DOCK11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5JSL3 / DOC11_HUMAN
Protein Name Dedicator of cytokinesis protein 11
Gene Name Name: DOCK11
Synonyms:ZIZ2;
Organism Homo sapiens (Human)

PRO ID PR:Q5JSL3
DAG View
PRO Name dedicator of cytokinesis protein 11 (human)
Definition A dedicator of cytokinesis protein 11 that is encoded in the genome of human.
Short Label hDOCK11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5JSL3 (DOCK11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 23186163
T16 Phosphorylation PhosphoSitePlus   UniProt 23186163
S23 Phosphorylation PhosphoSitePlus   UniProt 23186163
S25 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
Y57 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
T83 Phosphorylation HPRD   PhosphoSitePlus 18691976, 17081983, 20068231
S86 Phosphorylation HPRD   PhosphoSitePlus 18691976, 17081983
T87 Phosphorylation HPRD   PhosphoSitePlus 20068231
S98 Phosphorylation PhosphoSitePlus
S123 Phosphorylation HPRD 18452278
K132 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S158 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S161 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332
K163 Ubiquitination PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus   UniProt 19690332
S249 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus   UniProt 23186163
T322 Phosphorylation PhosphoSitePlus
S329 Phosphorylation HPRD   PhosphoSitePlus 17924679
T375 O-Glycosylation GlyGen 27655845, 29351928
S412 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S440 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20230923, 19651622, ...24275569, 19690332, 20068231
K498 Ubiquitination PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
Y571 Phosphorylation PhosphoSitePlus
K631 Acetylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
T731 Phosphorylation PhosphoSitePlus
T1010 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
K1147 Ubiquitination PhosphoSitePlus
Y1188 Phosphorylation PhosphoSitePlus
S1208 Phosphorylation PhosphoSitePlus
T1221 Phosphorylation PhosphoSitePlus
Y1223 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation HPRD   PhosphoSitePlus 19651622
S1237 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20230923
S1240 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20230923
T1247 Phosphorylation HPRD 19651622
S1267 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus
Y1271 Phosphorylation PhosphoSitePlus
Y1277 Phosphorylation PhosphoSitePlus
Y1288 Phosphorylation PhosphoSitePlus
S1350 Phosphorylation PhosphoSitePlus
T1352 Phosphorylation PhosphoSitePlus
T1378 Phosphorylation PhosphoSitePlus
T1620 Phosphorylation HPRD 20068231
S1624 Phosphorylation HPRD 20068231
S1636 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1642 Phosphorylation HPRD 20068231
T1790 Phosphorylation PhosphoSitePlus
T1809 Phosphorylation PhosphoSitePlus
K2017 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T83 A83 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T83 M83 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K132 T132 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K138 N138 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S158 F158 Biomuta DOID:4159 / skin cancer [ cosmic ]
S161 F161 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:1319 / brain cancer [ icgc ]
Y248 D248 Biomuta DOID:1324 / lung cancer [ cosmic ]
S277 N277 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S296 I296 Biomuta DOID:3571 / liver cancer [ cosmic ]
S296 C296 Biomuta DOID:363 / uterine cancer [ icgc ]
T322 I322 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S437 I437 Biomuta DOID:263 / kidney cancer [ cosmic ]
T505 M505 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K656 E656 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1010 I1010 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y1188 C1188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1240 C1240 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1240 F1240 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1350 L1350 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1350 T1350 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T1352 A1352 Biomuta DOID:363 / uterine cancer [ icgc ]
T1378 A1378 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1624 N1624 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]