iPTMnet Report for Q5JRX3 (PITRM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5JRX3 / PREP_HUMAN
Protein Name Presequence protease, mitochondrial precursor
Gene Name Name: PITRM1
Synonyms:KIAA1104;
Organism Homo sapiens (Human)

PRO ID PR:Q5JRX3
DAG View
PRO Name presequence protease, mitochondrial (human)
Definition A presequence protease, mitochondrial that is encoded in the genome of human.
Short Label hPITRM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5JRX3 (PITRM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y40 Phosphorylation PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
Y388 Phosphorylation PhosphoSitePlus
R424 Methylation PhosphoSitePlus
K473 Acetylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
R534 Methylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
S620 O-Glycosylation GlyGen 28510447, 33465208, 34229054
S717 Phosphorylation PhosphoSitePlus
Y721 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
T731 Phosphorylation PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
K759 Acetylation PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K770 Acetylation PhosphoSitePlus
K884 Acetylation PhosphoSitePlus
K884 Ubiquitination PhosphoSitePlus
K946 Acetylation PhosphoSitePlus
K946 Ubiquitination PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
R1007 Methylation PhosphoSitePlus
T1011 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y40 C40 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y258 H258 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K287 R287 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y388 C388 Biomuta DOID:1324 / lung cancer [ cosmic ]
R424 Q424 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
R424 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S530 F530 Biomuta [ cosmic ]
R534 T534 Biomuta DOID:1612 / breast cancer [ cosmic ]
T731 M731 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]