iPTMnet Report for Q5JQC9 (AKAP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5JQC9 / AKAP4_HUMAN
Protein Name A-kinase anchor protein 4 precursor
Gene Name Name: AKAP4
Synonyms:AKAP82;
Organism Homo sapiens (Human)

PRO ID PR:Q5JQC9
DAG View
PRO Name A-kinase anchor protein 4 (human)
Definition An A-kinase anchor protein 4 that is encoded in the genome of human.
Short Label hAKAP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5JQC9 (AKAP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
Y57 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T265 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 27901058
S268 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus   UniProt 12509440
Y303 Phosphorylation PhosphoSitePlus   UniProt 12509440
S304 Phosphorylation PhosphoSitePlus   UniProt 12509440
S307 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T420 Phosphorylation PhosphoSitePlus
S432 Phosphorylation IEDB   PhosphoSitePlus 35494241
T441 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus   UniProt 12509440
Y448 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus   UniProt 12509440
S464 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S489 Phosphorylation PhosphoSitePlus
T491 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
Y554 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
T565 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
Y714 Phosphorylation PhosphoSitePlus
Y792 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 20068231
T7 Phosphorylation HPRD 20068231
T8 Phosphorylation HPRD 20068231
S11 Phosphorylation HPRD 20068231
S19 Phosphorylation HPRD 20068231
S62 Phosphorylation HPRD 12509440
S63 Phosphorylation HPRD 12509440
S64 Phosphorylation HPRD 12509440
S65 Phosphorylation HPRD 12509440
S151 Phosphorylation HPRD 12509440
T265 Phosphorylation HPRD 12509440
S268 Phosphorylation HPRD 12509440
S272 Phosphorylation HPRD 12509440
S293 Phosphorylation HPRD 12509440
S300 Phosphorylation HPRD 12509440
Y303 Phosphorylation HPRD 12509440
S304 Phosphorylation HPRD 12509440
S364 Phosphorylation HPRD 20068231
T420 Phosphorylation HPRD 20068231
S432 Phosphorylation HPRD 20068231
T441 Phosphorylation HPRD 20068231
S447 Phosphorylation HPRD 12509440
Y448 Phosphorylation HPRD 12509440
S450 Phosphorylation HPRD 12509440
S492 Phosphorylation HPRD 12509440
S536 Phosphorylation HPRD 12509440
S539 Phosphorylation HPRD 12509440, 18452278
Y554 Phosphorylation HPRD 18452278
T557 Phosphorylation HPRD 18452278
S665 Phosphorylation HPRD 12509440
S667 Phosphorylation HPRD 12509440
S817 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S355 Phosphorylation HPRD 20068231
T411 Phosphorylation HPRD 20068231
S423 Phosphorylation HPRD 20068231
T432 Phosphorylation HPRD 20068231
S530 Phosphorylation HPRD 18452278
Y545 Phosphorylation HPRD 18452278
T548 Phosphorylation HPRD 18452278
S808 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 Y5 Biomuta DOID:363 / uterine cancer [ icgc ]
S5 C5 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S11 Y11 Biomuta DOID:363 / uterine cancer [ icgc ]
S19 R19 Biomuta DOID:1319 / brain cancer [ icgc ]
Y57 F57 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S63 C63 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S64 I64 Biomuta DOID:363 / uterine cancer [ icgc ]
Y336 C336 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T411 K411 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T420 K420 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S450 Y450 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S484 A484 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S489 P489 Biomuta DOID:3571 / liver cancer [ cosmic ]
T491 N491 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S492 R492 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S530 * Biomuta [ cosmic ]
S539 * Biomuta [ cosmic ]
Y545 * Biomuta DOID:263 / kidney cancer [ cosmic ]
Y545 C545 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
Y545 D545 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T548 I548 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y554 * Biomuta DOID:263 / kidney cancer [ cosmic ]
Y554 C554 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
Y554 D554 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T557 I557 Biomuta DOID:1319 / brain cancer [ cosmic ]
T565 A565 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y714 H714 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S808 R808 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S808 G808 Biomuta DOID:1612 / breast cancer [ cosmic ]
S817 R817 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S817 G817 Biomuta DOID:1612 / breast cancer [ cosmic ]