iPTMnet Report Q5J8M3 EMC4

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q5J8M3 / EMC4_HUMAN
Protein Name	ER membrane protein complex subunit 4
Gene Name	Name: EMC4 Synonyms:TMEM85;ORFNames:HSPC184,PIG17;
Organism	Homo sapiens (Human)

PRO ID	PR:Q5J8M3 DAG View
PRO Name	ER membrane protein complex subunit 4 (human)
Definition	An ER membrane protein complex subunit 4 that is encoded in the genome of human.
Short Label	hEMC4
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q5J8M3 (EMC4) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T2	Acetylation		score1	UniProt	25489052, 22814378, 22223895, ...25944712
	T2	Phosphorylation		score1	PhosphoSitePlus
	R11	Methylation		score1	PhosphoSitePlus
	K16	Ubiquitination		score1	PhosphoSitePlus
	S32	Phosphorylation		score1	PhosphoSitePlus
	S36	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 17081983, ...24275569
	S41	Phosphorylation		score1	PhosphoSitePlus
	K50	Ubiquitination		score1	PhosphoSitePlus
	C69	Methylation		score1	IEDB	31844290

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T2	Phosphorylation		score0	HPRD	20058876
	S32	Phosphorylation		score0	HPRD	17081983
	S36	Phosphorylation		score0	HPRD	20166139, 18669648
	S41	Phosphorylation		score0	HPRD	17081983
	Y43	Phosphorylation		score0	HPRD	17081983

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
R11	L11	Biomuta		DOID:1324 / lung cancer [ cosmic ]
K16	E16	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]