iPTMnet Report for Q5HYA8 (TMEM67)
Protein Information
| UniProt AC / UniProt ID | Q5HYA8 / MKS3_HUMAN |
| Protein Name | Meckelin precursor |
| Gene Name | Name: TMEM67 Synonyms:MKS3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q5HYA8 |
| PRO Name | meckelin (human) |
| Definition | A meckelin that is encoded in the genome of human. |
| Short Label | hTMEM67 |
| Category | organism-gene |
DAG ViewQ5HYA8 (TMEM67) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N141 | N-Glycosylation | score3 | GlyGen UniProt | 34731008 | ||
| N179 | N-Glycosylation | score4 | GlyGen UniProt | 34731008, 24190977 | ||
| N242 | N-Glycosylation | score3 | GlyGen UniProt | 34731008 | ||
| N318 | N-Glycosylation | score3 | GlyGen UniProt | 34731008 | ||
| Y337 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K435 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S449 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T543 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 27869121 | ||
| K650 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K810 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y874 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K899 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K986 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| N318 | H318 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y337 | D337 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K986 | R986 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K986 | N986 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
