iPTMnet Report for Q5H9R7 (PPP6R3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5H9R7 / PP6R3_HUMAN
Protein Name Serine/threonine-protein phosphatase 6 regulatory subunit 3
Gene Name Name: PPP6R3
Synonyms:C11orf23,KIAA1558,PP6R3,SAPL,SAPS3;
Organism Homo sapiens (Human)

PRO ID PR:Q5H9R7
DAG View
PRO Name serine/threonine-protein phosphatase 6 regulatory subunit 3 (human)
Definition A serine/threonine-protein phosphatase 6 regulatory subunit 3 that is encoded in the genome of human.
Short Label hPPP6R3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5H9R7 (PPP6R3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K25 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
R207 Methylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
T343 Phosphorylation IEDB 35494241
K430 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S537 Phosphorylation phospho.ELM 15302935
K568 Ubiquitination PhosphoSitePlus
S579 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 19690332, 20068231
S617 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19369195, 15302935, 18669648, 24275569, 19690332, 20068231
K626 Ubiquitination PhosphoSitePlus
T631 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
S634 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
T643 Phosphorylation PhosphoSitePlus
N682 N-Glycosylation GlyGen 29671580
S722 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T727 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
T755 Phosphorylation PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
C844 S-Nitrosylation dbSNO 26338901
S851 Phosphorylation PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
N682 N-Glycosylation PRO 29671580
Site PTM Type PTM Enzyme Score Source PMID
S499 Phosphorylation HPRD 19651622, 15302935, 18669648, ...19664994, 20068231
S537 Phosphorylation HPRD 19413330, 18691976, 18212344, ...20230923, 18767875, 20058876, 19664995, 18452278, 17322306, 19664994, 18669648, 19651622, 20166139, 19415658, 20068231
T551 Phosphorylation HPRD 19651622, 17525332
S554 Phosphorylation HPRD 19651622, 17525332
S642 Phosphorylation HPRD 18669648
S660 Phosphorylation HPRD 17081983
S745 Phosphorylation HPRD 18077418
S771 Phosphorylation HPRD 17322306, 18691976
S773 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K25 N25 Biomuta DOID:363 / uterine cancer [ icgc ]
K25 T25 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R207 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R207 Q207 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S554 F554 Biomuta DOID:4159 / skin cancer [ cosmic ]
K626 E626 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S634 F634 Biomuta DOID:4159 / skin cancer [ cosmic ]
S660 Y660 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S852 G852 Biomuta DOID:2531 / hematologic cancer [ cosmic ]