iPTMnet Report for Q5H8C1 (FREM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5H8C1 / FREM1_HUMAN
Protein Name FRAS1-related extracellular matrix protein 1 precursor
Gene Name Name: FREM1
Synonyms:C9orf143,C9orf145,C9orf154;
Organism Homo sapiens (Human)

PRO ID PR:Q5H8C1
DAG View
PRO Name FRAS1-related extracellular matrix protein 1 (human)
Definition A FRAS1-related extracellular matrix protein 1 that is encoded in the genome of human.
Short Label hFREM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5H8C1 (FREM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
S950 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1306 Phosphorylation PhosphoSitePlus
Y1312 Phosphorylation PhosphoSitePlus
Y1768 Phosphorylation PhosphoSitePlus
S1769 Phosphorylation PhosphoSitePlus
S1772 Phosphorylation PhosphoSitePlus
S1858 Phosphorylation PhosphoSitePlus
Y1859 Phosphorylation PhosphoSitePlus
S1900 Phosphorylation PhosphoSitePlus
T1910 Phosphorylation PhosphoSitePlus
T1943 Phosphorylation PhosphoSitePlus
S1954 Phosphorylation PhosphoSitePlus
T1964 Phosphorylation PhosphoSitePlus
K1970 Ubiquitination PhosphoSitePlus
S2142 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S43 L43 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T112 N112 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y163 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1772 L1772 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1772 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1772 T1772 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1954 F1954 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2142 F2142 Biomuta [ cosmic ]