Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5GLZ8 / HERC4_HUMAN
Protein Name Probable E3 ubiquitin-protein ligase HERC4
Gene Name Name: HERC4
Synonyms:KIAA1593;
Organism Homo sapiens (Human)

PRO ID PR:Q5GLZ8
DAG View
PRO Name probable E3 ubiquitin-protein ligase HERC4 (human)
Definition A probable E3 ubiquitin-protein ligase HERC4 that is encoded in the genome of human.
Short Label hHERC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5GLZ8 (HERC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K27 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
Y147 Phosphorylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
S830 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K835 Ubiquitination PhosphoSitePlus
T886 Phosphorylation PhosphoSitePlus
K890 Ubiquitination PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus
K954 Ubiquitination PhosphoSitePlus
K959 Ubiquitination PhosphoSitePlus
T992 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
Y1018 Phosphorylation PhosphoSitePlus
T1024 Phosphorylation PhosphoSitePlus
K1033 Ubiquitination PhosphoSitePlus
K1037 Ubiquitination PhosphoSitePlus
K1043 Ubiquitination PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S830 Phosphorylation HPRD 17287340
Site PTM Type PTM Enzyme Score Source PMID
S822 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K572 T572 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K730 E730 Biomuta DOID:363 / uterine cancer [ tcga ]
K827 N827 Biomuta DOID:363 / uterine cancer [ tcga ]
S830 Y830 Biomuta DOID:3571 / liver cancer [ icgc ]
T886 P886 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1055 R1055 Biomuta DOID:363 / uterine cancer [ tcga ]