iPTMnet Report for Q5GLZ8 (HERC4)
Protein Information
| UniProt AC / UniProt ID | Q5GLZ8 / HERC4_HUMAN |
| Protein Name | Probable E3 ubiquitin-protein ligase HERC4 |
| Gene Name | Name: HERC4 Synonyms:KIAA1593; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q5GLZ8 |
| PRO Name | probable E3 ubiquitin-protein ligase HERC4 (human) |
| Definition | A probable E3 ubiquitin-protein ligase HERC4 that is encoded in the genome of human. |
| Short Label | hHERC4 |
| Category | organism-gene |
DAG ViewQ5GLZ8 (HERC4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K27 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K34 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K70 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C91 | Methylation | score1 | IEDB | 31844290 | ||
| Y146 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y147 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K165 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K176 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K177 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S180 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K237 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K243 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y246 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C301 | Methylation | score1 | IEDB | 31844290 | ||
| K336 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K365 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C392 | Methylation | score1 | IEDB | 31844290 | ||
| K397 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K409 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K469 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K488 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K493 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K572 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K606 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K730 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K769 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K827 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S830 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17287340 | ||
| K835 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T886 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K890 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K922 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K954 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K959 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T992 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1004 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1018 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1024 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1033 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1037 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K1043 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1055 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K34 | T34 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| K165 | T165 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K218 | T218 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K572 | T572 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K730 | E730 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K730 | N730 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] | |
| K827 | N827 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T886 | P886 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K922 | E922 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] |
