iPTMnet Report for Q5FBB7 (SGO1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5FBB7 / SGO1_HUMAN
Protein Name Shugoshin 1
Gene Name Name: SGO1
Synonyms:SGOL1;
Organism Homo sapiens (Human)

PRO ID PR:Q5FBB7
DAG View
PRO Name shugoshin 1 (human)
Definition A shugoshin 1 that is encoded in the genome of human.
Short Label hSGO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5FBB7 (SGO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 17621308
S14 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   Signor 17621308
K19 Ubiquitination PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S73 Phosphorylation neXtProt 18331714
S73 Phosphorylation P53350 (PLK1) neXtProt 18331714
S119 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
T146 Phosphorylation neXtProt 18331714
T146 Phosphorylation P53350 (PLK1) neXtProt 18331714
S193 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S256 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T346 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P   Signor 24055156, 23242214, 29263825, ...25173175
T346 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 23242214, 24055156
T417 Phosphorylation PhosphoSitePlus
T425 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T429 Phosphorylation PhosphoSitePlus
T433 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S436 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 19015261, 18220336
S440 Phosphorylation RLIMS-P 19015261
Y450 Phosphorylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S507 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 17621308, 20068231
S507 Phosphorylation P51955 (NEK2) neXtProt   PhosphoSitePlus   Signor 17621308
Site PTM Type PTM Enzyme Score Source PMID
S256 Phosphorylation HPRD 19413330, 18669648, 20068231
T425 Phosphorylation HPRD 18669648
T429 Phosphorylation HPRD 20068231
T433 Phosphorylation HPRD 18669648
S436 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD 20068231
S461 Phosphorylation HPRD 20068231
S468 Phosphorylation HPRD 19007248
T500 Phosphorylation HPRD 20068231
S507 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S207 Phosphorylation HPRD 20068231
S209 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 19007248
T248 Phosphorylation HPRD 20068231
S255 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S190 Phosphorylation HPRD 20068231
S192 Phosphorylation HPRD 20068231
S199 Phosphorylation HPRD 19007248
T231 Phosphorylation HPRD 20068231
S238 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S207 Phosphorylation HPRD 20068231
S209 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 19007248
T248 Phosphorylation HPRD 20068231
S255 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S190 Phosphorylation HPRD 20068231
S192 Phosphorylation HPRD 20068231
S199 Phosphorylation HPRD 19007248
T231 Phosphorylation HPRD 20068231
S238 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S256 Phosphorylation HPRD 19413330, 18669648, 20068231
T425 Phosphorylation HPRD 18669648
T429 Phosphorylation HPRD 20068231
T433 Phosphorylation HPRD 18669648
S436 Phosphorylation HPRD 20068231
S459 Phosphorylation HPRD 20068231
S461 Phosphorylation HPRD 20068231
S468 Phosphorylation HPRD 19007248
T500 Phosphorylation HPRD 20068231
S507 Phosphorylation HPRD 18669648, 20068231


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P53350 (hPLK1) Interaction PR:Q5FBB7 (hSGO1) PRO
PR:Q53HL2 (hCDCA8) Interaction PR:Q5FBB7 (hSGO1) PRO
PR:Q5FBB7 (hSGO1) Interaction PR:Q96GD4 (hAURKB) PRO
PR:Q5FBB7 (hSGO1) Interaction PR:O60566 (hBUB1B) PRO
PR:Q5FBB7 (hSGO1) Interaction PR:P53350 (hPLK1) PRO
PR:Q5FBB7 (hSGO1) Interaction PR:P30153 (hPPP2R1A) PRO 16580887
PR:Q5FBB7 (hSGO1) Interaction PR:P67775 (hPPP2CA) PRO 16580887
PR:Q5FBB7 (hSGO1) Interaction PR:Q53HL2 (hCDCA8) PRO
PR:Q5FBB7 (hSGO1) Interaction PR:Q9NQS7 (hINCENP) PRO
PR:Q5FBB7 (hSGO1) Interaction PR:Q13362 (hPPP2R5C) PRO 16580887
PR:Q9NQS7 (hINCENP) Interaction PR:Q5FBB7 (hSGO1) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 R14 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S38 C38 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S119 F119 Biomuta DOID:4159 / skin cancer [ cosmic ]
S201 N201 Biomuta DOID:4159 / skin cancer [ cosmic ]
S238 Y238 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc ]
S255 Y255 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y450 C450 Biomuta DOID:1324 / lung cancer [ cosmic ]
K454 T454 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S507 Y507 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]