iPTMnet Report for Q5D1E8 (ZC3H12A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5D1E8 / ZC12A_HUMAN
Protein Name Endoribonuclease ZC3H12A
Gene Name Name: ZC3H12A
Synonyms:MCPIP;
Organism Homo sapiens (Human)

PRO ID PR:Q5D1E8
DAG View
PRO Name endoribonuclease ZC3H12A (human)
Definition An endoribonuclease ZC3H12A that is encoded in the genome of human.
Short Label hZC3H12A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5D1E8 (ZC3H12A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K57 Sumoylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus   UniProt 23186163
K117 Ubiquitination PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus   UniProt 23186163
S359 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
S386 Phosphorylation HPRD   PhosphoSitePlus 18691976
S389 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
T397 Phosphorylation PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92900 (UPF1) T28 Q5D1E8 (ZC3H12A) unknown eFIP 31329944


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K117 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S344 P344 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S344 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S364 C364 Biomuta DOID:1324 / lung cancer [ cosmic ]
S386 F386 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S497 R497 Biomuta DOID:1324 / lung cancer [ cosmic ]