iPTMnet Report for Q58WW2 (DCAF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q58WW2 / DCAF6_HUMAN
Protein Name DDB1- and CUL4-associated factor 6
Gene Name Name: DCAF6
Synonyms:IQWD1;ORFNames:MSTP055;
Organism Homo sapiens (Human)

PRO ID PR:Q58WW2
DAG View
PRO Name DDB1- and CUL4-associated factor 6 (human)
Definition A DDB1- and CUL4-associated factor 6 that is encoded in the genome of human.
Short Label hDCAF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q58WW2 (DCAF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R3 Methylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
C53 Methylation IEDB 31844290
K101 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
R235 Methylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
R313 Methylation PhosphoSitePlus
S336 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 27920218, ...18669648, 24275569, 19690332, 20068231
R364 Methylation PhosphoSitePlus
R366 Methylation PhosphoSitePlus
R368 Methylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
C593 S-Nitrosylation dbSNO 26338901
K606 Ubiquitination PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus   UniProt 20068231
T654 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 24275569
S657 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...24275569, 19690332, 20068231
K694 Ubiquitination PhosphoSitePlus
K800 Ubiquitination PhosphoSitePlus
S847 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S850 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S336 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
S649 Phosphorylation HPRD 19651622, 19415658, 20068231
T654 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 19415658, 20068231
S657 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S847 Phosphorylation HPRD 18669648, 18452278
S850 Phosphorylation HPRD 18669648, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S336 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
S459 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S669 Phosphorylation HPRD 19651622, 19415658, 20068231
T674 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 19415658, 20068231
S677 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S867 Phosphorylation HPRD 18669648, 18452278
S870 Phosphorylation HPRD 18669648, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R3 Q3 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K101 Q101 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K183 E183 Biomuta DOID:263 / kidney cancer [ cosmic ]
S215 L215 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R235 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R313 C313 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
S336 N336 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K575 E575 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S649 P649 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S669 P669 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K800 E800 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S847 L847 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S867 L867 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]