iPTMnet Report for Q58EX7 (PLEKHG4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q58EX7 / PKHG4_HUMAN
Protein Name Puratrophin-1
Gene Name Name: PLEKHG4
Synonyms:PRTPHN1;
Organism Homo sapiens (Human)

PRO ID PR:Q58EX7
DAG View
PRO Name puratrophin-1 (human)
Definition A puratrophin-1 that is encoded in the genome of human.
Short Label hPLEKHG4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q58EX7 (PLEKHG4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S67 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S114 Phosphorylation IEDB 35494241
S142 Phosphorylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
T419 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
K784 Ubiquitination PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K846 Ubiquitination PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus
Y970 Phosphorylation PhosphoSitePlus
K971 Ubiquitination PhosphoSitePlus
K975 Ubiquitination PhosphoSitePlus
K1049 Ubiquitination PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
R1064 Methylation PhosphoSitePlus
Y1068 Phosphorylation PhosphoSitePlus
K1071 Ubiquitination PhosphoSitePlus
C1190 S-Nitrosylation dbSNO 26338901


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 F11 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T419 M419 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K608 N608 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K674 M674 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R1064 H1064 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R1064 C1064 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1071 N1071 Biomuta DOID:3571 / liver cancer [ cosmic ]
C1190 F1190 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C1190 Y1190 Biomuta DOID:9256 / colorectal cancer [ cosmic ]