iPTMnet Report for Q58DX5 (NAALADL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q58DX5 / NADL2_HUMAN
Protein Name Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2
Gene Name Name: NAALADL2
Organism Homo sapiens (Human)

PRO ID PR:Q58DX5
DAG View
PRO Name inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (human)
Definition An inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 that is encoded in the genome of human.
Short Label hNAALADL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q58DX5 (NAALADL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y35 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y106 Phosphorylation PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
N295 N-Glycosylation GlyGen 29741879
Y524 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
N534 N-Glycosylation GlyGen 29741879
T740 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y106 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S92 L92 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y106 N106 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y106 C106 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y266 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S280 C280 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S529 N529 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
N534 D534 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T740 A740 Biomuta DOID:363 / uterine cancer [ icgc ]