iPTMnet Report for Q56NI9 (ESCO2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q56NI9 / ESCO2_HUMAN
Protein Name N-acetyltransferase ESCO2
Gene Name Name: ESCO2
Organism Homo sapiens (Human)

PRO ID PR:Q56NI9
DAG View
PRO Name N-acetyltransferase ESCO2 (human)
Definition An N-acetyltransferase ESCO2 that is encoded in the genome of human.
Short Label hESCO2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q56NI9 (ESCO2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
C16 Methylation IEDB 31844290
S29 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
K33 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
S75 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 32897882, 18669648, 23186163, ...20068231
Y93 Phosphorylation PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
K111 Sumoylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K138 Acetylation PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Sumoylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
K156 Sumoylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Sumoylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus   UniProt 23186163
T233 Phosphorylation PhosphoSitePlus
S244 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T248 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K253 Sumoylation PhosphoSitePlus
C263 Methylation IEDB 31844290
S278 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus   UniProt 23186163
K317 Ubiquitination PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
K337 Methylation PhosphoSitePlus
K337 Sumoylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K372 Sumoylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K451 Sumoylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
R487 Methylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
S512 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 17081983, 20068231
S70 Phosphorylation HPRD 20068231
S75 Phosphorylation HPRD 18669648, 19664995, 20068231
S159 Phosphorylation HPRD 20068231
S244 Phosphorylation HPRD 18669648, 20068231
S312 Phosphorylation HPRD 19413330
S512 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K42 E42 Biomuta DOID:1319 / brain cancer [ cosmic ]
K42 T42 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K138 N138 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K147 E147 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S159 L159 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S222 L222 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T248 A248 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S278 N278 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K280 T280 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K284 Q284 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S312 Y312 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S320 Y320 Biomuta DOID:363 / uterine cancer [ icgc ]
S320 F320 Biomuta DOID:4159 / skin cancer [ cosmic ]
K451 N451 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K498 R498 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S512 F512 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]