iPTMnet Report for Q53QZ3 (ARHGAP15)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q53QZ3 / RHG15_HUMAN
Protein Name Rho GTPase-activating protein 15
Gene Name Name: ARHGAP15
ORFNames:BM-024,BM-030,BM-046;
Organism Homo sapiens (Human)

PRO ID PR:Q53QZ3
DAG View
PRO Name Rho GTPase-activating protein 15 (human)
Definition A Rho GTPase-activating protein 15 that is encoded in the genome of human.
Short Label hARHGAP15
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q53QZ3 (ARHGAP15) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
N15 N-Glycosylation GlyGen 24190977
S39 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K51 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus   UniProt 19690332
S111 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
S196 O-Glycosylation GlyGen 29351928
K206 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 C4 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S7 C7 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S7 Y7 Biomuta DOID:363 / uterine cancer [ icgc ]
S64 L64 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S64 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K82 I82 Biomuta DOID:4159 / skin cancer [ cosmic ]
K88 Q88 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K118 E118 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K121 R121 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K121 E121 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K133 N133 Biomuta DOID:1324 / lung cancer [ cosmic ]
S196 G196 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K206 E206 Biomuta DOID:4159 / skin cancer [ cosmic ]
S211 C211 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S211 F211 Biomuta DOID:4159 / skin cancer [ cosmic ]
T213 S213 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S233 Y233 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S241 C241 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S243 Y243 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S243 F243 Biomuta DOID:5158 / pleural cancer [ cosmic ]
K271 I271 Biomuta DOID:1324 / lung cancer [ cosmic ]
K275 E275 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S292 F292 Biomuta [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
K299 Q299 Biomuta DOID:184 / bone cancer [ cosmic ]
K392 N392 Biomuta DOID:4159 / skin cancer [ cosmic ]