iPTMnet Report for Q53H80 (AKIRIN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q53H80 / AKIR2_HUMAN
Protein Name Akirin-2
Gene Name Name: AKIRIN2
Synonyms:C6orf166;
Organism Homo sapiens (Human)

PRO ID PR:Q53H80
DAG View
PRO Name akirin-2 (human)
Definition An akirin-2 that is encoded in the genome of human.
Short Label hAKIRIN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q53H80 (AKIRIN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Methylation PhosphoSitePlus
S18 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18847512, ...19651622, 18669648, 20068231
S18 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S21 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...18847512, 19664994, 19664995, 19651622, 18669648, 19690332, 20068231
S21 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S39 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
S57 Phosphorylation IEDB   PhosphoSitePlus 32387766
T78 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
C152 Methylation IEDB 31844290
K174 Ubiquitination PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S125 L125 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K174 Q174 Biomuta DOID:363 / uterine cancer [ icgc ]
Y201 F201 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S203 * Biomuta DOID:4362 / cervical cancer [ cosmic ]