Protein Information

Cytoscape View

UniProt AC / UniProt ID Q53GS9 / SNUT2_HUMAN
Protein Name U4/U6.U5 tri-snRNP-associated protein 2
Gene Name Name: USP39
Organism Homo sapiens (Human)

DAG View
PRO Name U4/U6.U5 tri-snRNP-associated protein 2 (human)
Definition A U4/U6.U5 tri-snRNP-associated protein 2 that is encoded in the genome of human.
Short Label hUSP39
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q53GS9 (USP39) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R22 Methylation PhosphoSitePlus
S42 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S46 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163, 17081983
S58 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
K73 Sumoylation PhosphoSitePlus
S82 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 17287340, 20068231
S97 Phosphorylation PhosphoSitePlus
C105 S-Nitrosylation dbSNO 26338901
K207 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
Y259 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K291 Methylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K428 Acetylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
R481 Methylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S42 Phosphorylation HPRD 17287340
S43 Phosphorylation HPRD 17081983
S46 Phosphorylation HPRD 18767875, 17287340, 17081983
S82 Phosphorylation HPRD 17322306, 17287340, 18767875, ...20058876, 18452278, 19651622, 18669648, 20068231
S97 Phosphorylation HPRD 20068231
S352 Phosphorylation HPRD 20068231
T357 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K73 E73 Biomuta DOID:1909 / melanoma [ cosmic ]
Y259 H259 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K428 N428 Biomuta DOID:3571 / liver cancer [ icgc ]
K434 N434 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]