Protein Information

Cytoscape View


UniProt AC / UniProt ID Q53GQ0 / DHB12_HUMAN
Protein Name Very-long-chain 3-oxoacyl-CoA reductase
Gene Name Name: HSD17B12
Synonyms:SDR12C1;
Organism Homo sapiens (Human)

PRO ID PR:Q53GQ0
DAG View
PRO Name very-long-chain 3-oxoacyl-CoA reductase (human)
Definition A very-long-chain 3-oxoacyl-CoA reductase that is encoded in the genome of human.
Short Label hHSD17B12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q53GQ0 (HSD17B12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y12 Phosphorylation PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
C215 S-Nitrosylation dbSNO 26338901
K223 Ubiquitination PhosphoSitePlus
Y233 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S164 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y12 * Biomuta DOID:363 / uterine cancer [ tcga ]
K72 N72 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S91 A91 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
S164 P164 Biomuta DOID:1909 / melanoma [ cosmic ]
S164 F164 Biomuta DOID:1909 / melanoma [ tcga ]
T169 A169 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K223 R223 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K299 N299 Biomuta DOID:3571 / liver cancer [ icgc ]