iPTMnet Report for Q53GL7 (PARP10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q53GL7 / PAR10_HUMAN
Protein Name Protein mono-ADP-ribosyltransferase PARP10
Gene Name Name: PARP10
Organism Homo sapiens (Human)

PRO ID PR:Q53GL7
DAG View
PRO Name protein mono-ADP-ribosyltransferase PARP10 (human)
Definition A protein mono-ADP-ribosyltransferase PARP10 that is encoded in the genome of human.
Short Label hPARP10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q53GL7 (PARP10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
T101 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 16455663
T101 Phosphorylation P24941 (CDK2) PhosphoSitePlus 16455663
S128 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S324 Phosphorylation HPRD 20068231
S331 Phosphorylation HPRD 20068231
S342 O-Glycosylation GlyGen 29351928
S356 O-Glycosylation GlyGen 29351928
S378 Phosphorylation PhosphoSitePlus   UniProt 24275569
S407 Phosphorylation PhosphoSitePlus
T420 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus   UniProt 24275569
S431 Phosphorylation PhosphoSitePlus   UniProt 24275569
T601 Phosphorylation PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
C757 Methylation IEDB 31844290
K916 Acetylation PhosphoSitePlus   UniProt 19608861
K916 Ubiquitination PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
S1011 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1022 Phosphorylation HPRD   PhosphoSitePlus 20068231
T1025 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K274 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K274 N274 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S378 I378 Biomuta DOID:4159 / skin cancer [ cosmic ]
C757 Y757 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S925 F925 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1011 F1011 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]