Protein Information

Cytoscape View


UniProt AC / UniProt ID Q53ET0 / CRTC2_HUMAN
Protein Name CREB-regulated transcription coactivator 2
Gene Name Name: CRTC2
Synonyms:TORC2;
Organism Homo sapiens (Human)

PRO ID PR:Q53ET0
DAG View
PRO Name CREB-regulated transcription coactivator 2 (human)
Definition A CREB-regulated transcription coactivator 2 that is encoded in the genome of human.
Short Label hCRTC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q53ET0 (CRTC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
T3 Phosphorylation HPRD 20068231
S4 Phosphorylation HPRD 20068231
S17 Phosphorylation PhosphoSitePlus
K25 Acetylation PhosphoSitePlus
K25 Sumoylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S64 Phosphorylation HPRD   PhosphoSitePlus 20068231
S65 Phosphorylation PhosphoSitePlus
Y67 Phosphorylation HPRD   PhosphoSitePlus 18669648
S70 Phosphorylation P57059 (SIK1) , Q9Y2K2 (SIK3) HPRD   PhosphoSitePlus   Signor   UniProt 16306228, 18669648, 15454081, ...19690332
S79 Phosphorylation HPRD   PhosphoSitePlus 18669648
S86 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 19690332
S90 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15454081, 18669648, 24275569, ...19690332
S94 Phosphorylation PhosphoSitePlus
R106 Methylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation HPRD   PhosphoSitePlus 18669648
S131 Phosphorylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
S136 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15454081, 18669648
K156 Sumoylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
R161 Methylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
S170 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 21892142
S171 Phosphorylation Q9H0K1 (SIK2) , Q9Y2K2 (SIK3) , P54646 (PRKAA2) , P57059 (SIK1) , Q7KZI7 (MARK2) HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20551288, 16306228, 16684769, ...23584792, 16308421, 17210223, 18626018, 24755741, 16148943, 16817901, 18669648, 19254569, 18348280, 15454081, 20577053
S173 Phosphorylation HPRD   PhosphoSitePlus 18669648
T177 Phosphorylation HPRD   PhosphoSitePlus 18669648
S183 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus   UniProt 19690332
R201 Methylation PhosphoSitePlus
K224 Sumoylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
K228 Sumoylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S274 Phosphorylation Q7KZI7 (MARK2) , P57059 (SIK1) neXtProt   RLIMS-P   UniProt 18348280, 20551288, 18626018, ...31355336
S306 Phosphorylation P57059 (SIK1) HPRD   neXtProt   UniProt 18348280, 20551288, 15454081
S336 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
S348 Phosphorylation Q9Y2K2 (SIK3) , P57059 (SIK1) HPRD   PhosphoSitePlus   Signor 16306228
S366 Phosphorylation HPRD   PhosphoSitePlus 20068231
S368 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15454081
S375 Phosphorylation HPRD 20068231
S386 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S393 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 15454081
S398 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
S433 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus   UniProt 23186163, 16964243, 18220336, ...18847512, 18669648, 18707149, 15454081, 19690332, 20068231
S436 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K453 Sumoylation PhosphoSitePlus
S456 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15454081, 20068231
T458 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
S460 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
T462 Phosphorylation HPRD 20068231
Y486 Phosphorylation HPRD 18669648
Y488 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19690332, 20068231
S489 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15454081, 18669648, 20068231
S490 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S492 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15454081
T497 Phosphorylation PhosphoSitePlus
T501 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
S504 Phosphorylation PhosphoSitePlus
C515 S-Nitrosylation dbSNO 26338901
S519 Phosphorylation PhosphoSitePlus
S613 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19651622, 18669648, ...24275569, 15454081, 19690332, 20068231
T620 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
S624 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18767875, 18669648, ...19690332, 20068231
S628 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045522 (hCRTC2/Phos:1) pS171 PRO 16684769, 16817901


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31749 (AKT1) S473 Q53ET0 (CRTC2) inhibited_association eFIP 22384145
Phosphorylation Q12778 (FOXO1) T24 Q53ET0 (CRTC2) inhibited_association eFIP 22384145


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R106 Q106 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S127 N127 Biomuta DOID:363 / uterine cancer [ tcga ]
Y134 H134 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
Y134 N134 Biomuta DOID:2394 / ovarian cancer [ icgc ]
R161 Q161 Biomuta DOID:0070003 / blastoma [ cosmic ]
T169 I169 Biomuta DOID:363 / uterine cancer [ tcga ]
S171 F171 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S173 C173 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S183 G183 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T187 I187 Biomuta DOID:1909 / melanoma [ tcga ]
T187 A187 Biomuta DOID:4362 / cervical cancer [ tcga ]
R201 S201 Biomuta DOID:3571 / liver cancer [ icgc ]
K233 N233 Biomuta DOID:2596 / larynx cancer [ cosmic ]
S336 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S375 Y375 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S375 F375 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
S456 L456 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y488 F488 Biomuta DOID:1324 / lung cancer [ cosmic ]
T620 I620 Biomuta DOID:3070 / malignant glioma [ tcga ]
S623 F623 Biomuta DOID:1909 / melanoma [ cosmic ]