iPTMnet Report for Q52LR7 (EPC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q52LR7 / EPC2_HUMAN
Protein Name Enhancer of polycomb homolog 2
Gene Name Name: EPC2
Organism Homo sapiens (Human)

PRO ID PR:Q52LR7
DAG View
PRO Name enhancer of polycomb homolog 2 (human)
Definition An enhancer of polycomb homolog 2 that is encoded in the genome of human.
Short Label hEPC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q52LR7 (EPC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD   PhosphoSitePlus 20068231
K3 Methylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
S119 Phosphorylation HPRD   PhosphoSitePlus 18452278
K131 Ubiquitination PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
Y296 Phosphorylation IEDB 35494241
K324 Sumoylation PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus
S349 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
S538 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...20068231
S540 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S558 O-Glycosylation GlyGen 34846842, 31637018, 30059200, ...35254053, 34019948, 31492838, 35289036, 29351928, 29237092
T567 Phosphorylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
T623 Phosphorylation PhosphoSitePlus
T750 O-Glycosylation GlyGen 34846842, 31637018, 30059200, ...35254053, 34019948, 31492838, 35289036, 29351928, 29237092
S751 O-Glycosylation GlyGen 34846842, 31637018, 30059200, ...35254053, 34019948, 31492838, 35289036, 29351928, 29237092
S754 Phosphorylation PhosphoSitePlus   UniProt 23186163
T756 Phosphorylation PhosphoSitePlus
S780 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K23 N23 Biomuta DOID:2021 / placenta cancer [ cosmic ]
K131 N131 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y169 N169 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S349 F349 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S349 A349 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y408 C408 Biomuta DOID:363 / uterine cancer [ cosmic ]
S538 R538 Biomuta DOID:3571 / liver cancer [ cosmic ]
S538 C538 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S538 I538 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T567 I567 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T567 N567 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S754 L754 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]