iPTMnet Report for Q504Q3 (PAN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q504Q3 / PAN2_HUMAN
Protein Name PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Gene Name Name: PAN2
Synonyms:KIAA0710,USP52;
Organism Homo sapiens (Human)

PRO ID PR:Q504Q3
DAG View
PRO Name PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (human)
Definition A PAN2-PAN3 deadenylation complex catalytic subunit PAN2 that is encoded in the genome of human.
Short Label hPAN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q504Q3 (PAN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K134 Ubiquitination PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
R265 Methylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
R422 Methylation PhosphoSitePlus
R432 Methylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus   RLIMS-P 33097710
S474 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
T673 Phosphorylation PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
T683 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
Y699 Phosphorylation PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
T728 Phosphorylation PhosphoSitePlus
T731 Phosphorylation PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
S791 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S800 Phosphorylation PhosphoSitePlus
K816 Acetylation PhosphoSitePlus
K882 Acetylation PhosphoSitePlus
K935 Ubiquitination PhosphoSitePlus
K1001 Ubiquitination PhosphoSitePlus
S1003 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P   Signor 33097710
C1012 Methylation IEDB 31844290
Y1028 Phosphorylation PhosphoSitePlus
Y1038 Phosphorylation PhosphoSitePlus
Y1042 Phosphorylation PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
K1063 Ubiquitination PhosphoSitePlus
K1149 Ubiquitination PhosphoSitePlus
K1168 Ubiquitination PhosphoSitePlus
T1188 Phosphorylation PhosphoSitePlus
S1189 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243
Site PTM Type PTM Enzyme Score Source PMID
S791 Phosphorylation HPRD 18669648
S1189 Phosphorylation HPRD 19413330, 16964243
Site PTM Type PTM Enzyme Score Source PMID
S787 Phosphorylation HPRD 18669648
S1185 Phosphorylation HPRD 19413330, 16964243


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R422 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R422 Q422 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R432 C432 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S469 R469 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S671 R671 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y699 C699 Biomuta DOID:1324 / lung cancer [ cosmic ]
T728 M728 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K769 N769 Biomuta DOID:363 / uterine cancer [ icgc ]
S787 R787 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S791 R791 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K935 N935 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1001 I1001 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K1063 R1063 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]