iPTMnet Report Q4VCS5 AMOT

Protein Information

UniProt AC / UniProt ID	Q4VCS5 / AMOT_HUMAN
Protein Name	Angiomotin
Gene Name	Name: AMOT Synonyms:KIAA1071;
Organism	Homo sapiens (Human)

PRO ID	PR:Q4VCS5 DAG View
PRO Name	angiomotin (human)
Definition	An angiomotin that is encoded in the genome of human.
Short Label	hAMOT
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q4VCS5 (AMOT) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position R24 K94 Y109 K113 K156 K167 S175 S182 T195 S196 S200 S213 K219 S229 R236 R280 R291 S305 S309 S312 R335 R412 S416 Y420 K464 K481 K496 Y527 T536 S538 K545 K553 R575 K585 K594 K595 Y599 K680 S712 S714 T717 S718 Y719 K739 T750 K758 T776 S780 S787 S823 Y836 S842 S847 T848 S852 S855 S1059 T1061	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all GlyGen IEDB PhosphoSitePlus RLIMS-P phospho.ELM	PMID
R24	Methylation		score1	PhosphoSitePlus
K94	Ubiquitination		score1	PhosphoSitePlus
Y109	Phosphorylation		score1	PhosphoSitePlus
K113	Ubiquitination		score1	PhosphoSitePlus
K156	Ubiquitination		score1	PhosphoSitePlus
K167	Ubiquitination		score1	PhosphoSitePlus
S175	Phosphorylation	Q9NRM7 (LATS2)	score4	PhosphoSitePlus RLIMS-P	24106267, 24225952, 24101513
S182	O-Glycosylation		score3	GlyGen	29249144, 35138101, 30620550, ...34019948, 32870666, 29217192, 29485866, 32119511, 35254053, 28657654
T195	O-Glycosylation		score3	GlyGen	29249144, 35138101, 30620550, ...34019948, 32870666, 29217192, 29485866, 32119511, 35254053, 28657654
S196	O-Glycosylation		score1	GlyGen	30620550
S200	O-Glycosylation		score1	GlyGen	29249144
S213	O-Glycosylation		score3	GlyGen	29249144, 35138101, 30620550, ...34019948, 32870666, 29217192, 29485866, 32119511, 35254053, 28657654
K219	Ubiquitination		score1	PhosphoSitePlus
S229	Phosphorylation		score1	PhosphoSitePlus
R236	Methylation		score1	PhosphoSitePlus
R280	Methylation		score1	PhosphoSitePlus
R291	Methylation		score1	PhosphoSitePlus
S305	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17525332
S309	Phosphorylation		score2	IEDB PhosphoSitePlus	27869121
S312	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17525332
R335	Methylation		score1	PhosphoSitePlus
R412	Methylation		score1	PhosphoSitePlus
S416	O-Glycosylation		score1	GlyGen	30620550
Y420	Phosphorylation		score1	PhosphoSitePlus
K464	Ubiquitination		score1	PhosphoSitePlus
K481	Ubiquitination		score1	PhosphoSitePlus
K496	Ubiquitination		score1	PhosphoSitePlus
Y527	Phosphorylation		score1	PhosphoSitePlus
T536	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	27321186
S538	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	27321186
K545	Acetylation		score1	PhosphoSitePlus
K553	Ubiquitination		score1	PhosphoSitePlus
R575	Methylation		score1	PhosphoSitePlus
K585	Ubiquitination		score1	PhosphoSitePlus
K594	Sumoylation		score1	PhosphoSitePlus
K595	Sumoylation		score1	PhosphoSitePlus
Y599	Phosphorylation		score1	PhosphoSitePlus
K680	Ubiquitination		score1	PhosphoSitePlus
S712	Phosphorylation		score1	PhosphoSitePlus
S714	Phosphorylation		score1	PhosphoSitePlus
T717	Phosphorylation		score1	PhosphoSitePlus
S718	Phosphorylation		score1	PhosphoSitePlus
Y719	Phosphorylation		score1	PhosphoSitePlus
K739	Ubiquitination		score1	PhosphoSitePlus
T750	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	27321186
K758	Ubiquitination		score1	PhosphoSitePlus
T776	O-Glycosylation		score3	GlyGen	29249144, 35138101, 30620550, ...34019948, 32870666, 29217192, 29485866, 32119511, 35254053, 28657654
S780	O-Glycosylation		score1	GlyGen	29249144
S787	Phosphorylation		score1	PhosphoSitePlus
S823	Phosphorylation		score1	PhosphoSitePlus
Y836	Phosphorylation		score1	PhosphoSitePlus
S842	Phosphorylation		score1	PhosphoSitePlus
S847	Phosphorylation	P24941 (CDK2)	score1	PhosphoSitePlus	18847512
T848	Phosphorylation	P24941 (CDK2)	score1	PhosphoSitePlus	18847512
S852	Phosphorylation	P24941 (CDK2)	score1	PhosphoSitePlus	18847512
S855	Phosphorylation	P24941 (CDK2)	score1	PhosphoSitePlus	18847512
S1059	Phosphorylation		score1	PhosphoSitePlus
T1061	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17287340

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S305 T308 Y310 T652	PTM Type Select all Phosphorylation	Score Select all 0	Source Select all HPRD	PMID
S305	Phosphorylation	score0	HPRD	19413330, 18452278
T308	Phosphorylation	score0	HPRD	19413330
Y310	Phosphorylation	score0	HPRD	19413330
T652	Phosphorylation	score0	HPRD	17287340

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all Q4VCS5 (AMOT)	Site Select all By amino acid All Threonine By position T750	Interactant Select all P46937 (YAP1)	Association type Select all inhibited_association	Source Select all eFIP	PMID
	Phosphorylation	Q4VCS5 (AMOT)	T750	P46937 (YAP1)	inhibited_association	eFIP	27321186

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position R24 S175 S182 S213 R236 S305 S309 R335 Y420 T536 S538 R575 K585 K595 Y599 S714 S780 S823 S842 S855	Variant Select all * C213 C823 F305 F420 F714 G175 H24 I213 I309 I823 L182 L305 L538 L780 L842 N536 N585 N595 P305 P855 S599	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
R24	H24	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S175	G175	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S182	L182	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S213	C213	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S213	I213	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R236	*	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S305	L305	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S305	F305	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S305	P305	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
S309	I309	Biomuta	DOID:363 / uterine cancer [ icgc ]
R335	*	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
Y420	F420	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
T536	N536	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S538	L538	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
R575	*	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K585	N585	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
K595	N595	Biomuta	DOID:363 / uterine cancer [ cosmic ]
Y599	S599	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S714	F714	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S780	L780	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc ]
S823	C823	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S823	I823	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S842	*	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S842	L842	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S855	P855	Biomuta	DOID:5041 / esophageal cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q4VCS5 (AMOT)

Protein Information

Interactive Sequence View

Q4VCS5 (AMOT) as Substrate

PTM-dependent PPI

PTM sites affected in variants