iPTMnet Report for Q4KWH8 (PLCH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q4KWH8 / PLCH1_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Gene Name Name: PLCH1
Synonyms:KIAA1069,PLCL3;
Organism Homo sapiens (Human)

PRO ID PR:Q4KWH8
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 that is encoded in the genome of human.
Short Label hPLCH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q4KWH8 (PLCH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S59 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
Y478 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
Y586 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus
Y907 Phosphorylation PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
S1027 Phosphorylation PhosphoSitePlus
S1028 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
T1099 Phosphorylation PhosphoSitePlus
S1129 Phosphorylation PhosphoSitePlus
S1131 Phosphorylation PhosphoSitePlus
Y1275 Phosphorylation PhosphoSitePlus
T1280 Phosphorylation PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
T1310 Phosphorylation PhosphoSitePlus
S1311 Phosphorylation PhosphoSitePlus
S1318 Phosphorylation PhosphoSitePlus
T1320 Phosphorylation PhosphoSitePlus
S1386 Phosphorylation PhosphoSitePlus
K1391 Methylation PhosphoSitePlus
S1416 Phosphorylation PhosphoSitePlus
S1433 Phosphorylation PhosphoSitePlus
Y1437 Phosphorylation PhosphoSitePlus
S1488 Phosphorylation PhosphoSitePlus
S1492 Phosphorylation PhosphoSitePlus
K1493 Ubiquitination PhosphoSitePlus
S1494 Phosphorylation PhosphoSitePlus
S1509 Phosphorylation PhosphoSitePlus
Y1511 Phosphorylation PhosphoSitePlus
S1517 Phosphorylation PhosphoSitePlus
T1520 Phosphorylation PhosphoSitePlus
T1521 Phosphorylation PhosphoSitePlus
T1530 O-Glycosylation GlyGen 30379171, 28411811
S1535 O-Glycosylation GlyGen 30379171, 28411811
S1535 Phosphorylation PhosphoSitePlus
T1543 O-Glycosylation GlyGen 30379171, 28411811
K1548 Ubiquitination PhosphoSitePlus
S1551 Phosphorylation PhosphoSitePlus
Y1562 Phosphorylation PhosphoSitePlus
S1630 Phosphorylation PhosphoSitePlus
T1631 Phosphorylation PhosphoSitePlus
Y1634 Phosphorylation PhosphoSitePlus
Y1638 Phosphorylation PhosphoSitePlus
Y1662 Phosphorylation PhosphoSitePlus
Y1688 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S68 F68 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y332 H332 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S464 G464 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S533 G533 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S563 Y563 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y586 C586 Biomuta DOID:4159 / skin cancer [ cosmic ]
S905 Y905 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y907 F907 Biomuta DOID:4159 / skin cancer [ cosmic ]
S923 G923 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S932 I932 Biomuta DOID:1324 / lung cancer [ cosmic ]
S932 R932 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1026 T1026 Biomuta DOID:169 / neuroendocrine tumor [ tcga ]
S1028 F1028 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1029 F1029 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1099 A1099 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S1131 C1131 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1275 F1275 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1307 Y1307 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1307 F1307 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1311 A1311 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1311 F1311 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1318 T1318 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1320 I1320 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1433 C1433 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1494 G1494 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1509 R1509 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1509 N1509 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T1543 I1543 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1551 Y1551 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1562 N1562 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1630 P1630 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T1631 S1631 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1634 * Biomuta DOID:1324 / lung cancer [ cosmic ]