Protein Information

Cytoscape View


UniProt AC / UniProt ID Q4FZB7 / KMT5B_HUMAN
Protein Name Histone-lysine N-methyltransferase KMT5B
Gene Name Name: KMT5B
Synonyms:SUV420H1;ORFNames:CGI-85;
Organism Homo sapiens (Human)

PRO ID PR:Q4FZB7
DAG View
PRO Name histone-lysine N-methyltransferase KMT5B (human)
Definition A histone-lysine N-methyltransferase KMT5B that is encoded in the genome of human.
Short Label hKMT5B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q4FZB7 (KMT5B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K20 Acetylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
K451 Acetylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
T544 Phosphorylation PhosphoSitePlus
K555 Sumoylation PhosphoSitePlus
T630 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
T730 Phosphorylation PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
Y791 Phosphorylation PhosphoSitePlus
T792 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S107 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K20 Acetylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
S107 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K170 N170 Biomuta DOID:363 / uterine cancer [ tcga ]
Y307 D307 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S397 Y397 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S527 L527 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10283 / prostate cancer [ icgc ]
K761 N761 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]