iPTMnet Report for Q49AN0 (CRY2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q49AN0 / CRY2_HUMAN
Protein Name Cryptochrome-2
Gene Name Name: CRY2
Synonyms:KIAA0658;
Organism Homo sapiens (Human)

PRO ID PR:Q49AN0
DAG View
PRO Name cryptochrome-2 (human)
Definition A cryptochrome-2 that is encoded in the genome of human.
Short Label hCRY2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q49AN0 (CRY2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Ubiquitination PRO
K126 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S266 Phosphorylation neXtProt 15298678
S266 Phosphorylation P28482 (MAPK1) neXtProt 15298678
T300 Phosphorylation PhosphoSitePlus   RLIMS-P 25855785
Y451 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
Y462 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S558 Phosphorylation neXtProt   PhosphoSitePlus 20123978
S558 Phosphorylation Q13627 (DYRK1A) neXtProt 20123978
S575 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047075 (hCRY2/PhosSer+) p PRO
PR:000047076 (hCRY2/pSerUbiq+) p PRO
PR:000047076 (hCRY2/pSerUbiq+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K242 T242 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S511 L511 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]