iPTMnet Report for Q495T6 (MMEL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q495T6 / MMEL1_HUMAN
Protein Name Membrane metallo-endopeptidase-like 1
Gene Name Name: MMEL1
Synonyms:MELL1,MMEL2,NEP2;
Organism Homo sapiens (Human)

PRO ID PR:Q495T6
DAG View
PRO Name membrane metallo-endopeptidase-like 1 (human)
Definition A membrane metallo-endopeptidase-like 1 that is encoded in the genome of human.
Short Label hMMEL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q495T6 (MMEL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
K183 Acetylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K183 N183 Biomuta DOID:3571 / liver cancer [ cosmic ]
S260 F260 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y263 C263 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
Y263 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S742 R742 Biomuta DOID:10534 / stomach cancer [ cosmic ]