iPTMnet Report for Q494U1 (PLEKHN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q494U1 / PKHN1_HUMAN
Protein Name Pleckstrin homology domain-containing family N member 1
Gene Name Name: PLEKHN1
Synonyms:CLPABP;
Organism Homo sapiens (Human)

PRO ID PR:Q494U1
DAG View
PRO Name pleckstrin homology domain-containing family N member 1 (human)
Definition A pleckstrin homology domain-containing family N member 1 that is encoded in the genome of human.
Short Label hPLEKHN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q494U1 (PLEKHN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25043870, 29180010
S17 Phosphorylation PhosphoSitePlus
K25 Methylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation UniProt 18191643
T383 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus   UniProt 18191643
T461 Phosphorylation PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus   UniProt 23186163
S571 Phosphorylation PhosphoSitePlus
Y580 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
T254 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S200 W200 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S200 L200 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S453 L453 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc ]
S521 C521 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]