iPTMnet Report for Q3ZCQ8 (TIMM50)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q3ZCQ8 / TIM50_HUMAN
Protein Name Mitochondrial import inner membrane translocase subunit TIM50 precursor
Gene Name Name: TIMM50
Synonyms:TIM50;ORFNames:PRO1512;
Organism Homo sapiens (Human)

PRO ID PR:Q3ZCQ8
DAG View
PRO Name mitochondrial import inner membrane translocase subunit TIM50 (human)
Definition A mitochondrial import inner membrane translocase subunit TIM50 that is encoded in the genome of human.
Short Label hTIMM50
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q3ZCQ8 (TIMM50) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
T28 Phosphorylation PhosphoSitePlus
R43 Methylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus   UniProt 23186163
K47 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
C133 Methylation IEDB 31844290
K232 Ubiquitination PhosphoSitePlus
C236 Methylation IEDB 31844290
C249 S-Nitrosylation dbSNO 26338901
S280 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus   UniProt 23186163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 L4 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R43 H43 Biomuta [ cosmic ]
S45 N45 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S61 R61 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
C249 Y249 Biomuta DOID:1319 / brain cancer [ cosmic ]
C249 F249 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S280 F280 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S341 F341 Biomuta DOID:4159 / skin cancer [ cosmic ]