iPTMnet Report for Q3ZCM7 (TUBB8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q3ZCM7 / TBB8_HUMAN
Protein Name Tubulin beta-8 chain
Gene Name Name: TUBB8
Organism Homo sapiens (Human)

PRO ID PR:Q3ZCM7
DAG View
PRO Name tubulin beta-8 chain (human)
Definition A tubulin beta-8 chain that is encoded in the genome of human.
Short Label hTUBB8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q3ZCM7 (TUBB8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus   UniProt 16371510
Y183 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K252 Sumoylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
R276 Methylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
R380 Methylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
Y425 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T72 I72 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S126 R126 Biomuta DOID:363 / uterine cancer [ tcga ]
K154 Q154 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S168 R168 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K252 N252 Biomuta DOID:2994 / germ cell cancer [ tcga ]
R276 Q276 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y281 * Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
K297 N297 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y340 N340 Biomuta DOID:1324 / lung cancer [ tcga ]
R380 H380 Biomuta DOID:363 / uterine cancer [ tcga ]
T399 M399 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]