iPTMnet Report for Q3ZCM7 (TUBB8)
Protein Information
UniProt AC / UniProt ID | Q3ZCM7 / TBB8_HUMAN |
Protein Name | Tubulin beta-8 chain |
Gene Name | Name: TUBB8 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q3ZCM7 |
PRO Name | tubulin beta-8 chain (human) |
Definition | A tubulin beta-8 chain that is encoded in the genome of human. |
Short Label | hTUBB8 |
Category | organism-gene |
Q3ZCM7 (TUBB8) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T7 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y59 | Phosphorylation | score1 | PhosphoSitePlus | |||
T72 | Phosphorylation | score1 | PhosphoSitePlus | |||
S75 | Phosphorylation | score1 | PhosphoSitePlus | |||
K122 | Ubiquitination | score1 | PhosphoSitePlus | |||
S126 | Phosphorylation | score1 | PhosphoSitePlus | |||
K154 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y159 | Phosphorylation | score1 | PhosphoSitePlus | |||
S168 | Phosphorylation | score1 | PhosphoSitePlus | |||
S172 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 16371510 | ||
Y183 | Phosphorylation | score1 | PhosphoSitePlus | |||
K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
K252 | Acetylation | score1 | PhosphoSitePlus | |||
K252 | Sumoylation | score1 | PhosphoSitePlus | |||
K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
T274 | Phosphorylation | score1 | PhosphoSitePlus | |||
S275 | Phosphorylation | score1 | PhosphoSitePlus | |||
R276 | Methylation | score1 | PhosphoSitePlus | |||
S278 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y281 | Phosphorylation | score1 | PhosphoSitePlus | |||
K297 | Ubiquitination | score1 | PhosphoSitePlus | |||
S339 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y340 | Phosphorylation | score1 | PhosphoSitePlus | |||
T351 | Phosphorylation | score1 | PhosphoSitePlus | |||
R380 | Methylation | score1 | PhosphoSitePlus | |||
K392 | Ubiquitination | score1 | PhosphoSitePlus | |||
T399 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y422 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y425 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T72 | I72 | Biomuta | DOID:1909 / melanoma [ icgc, tcga ] | |
S126 | R126 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
K154 | Q154 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ] | |
S168 | R168 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
K252 | N252 | Biomuta | DOID:2994 / germ cell cancer [ tcga ] | |
R276 | Q276 | Biomuta | DOID:2531 / hematologic cancer [ icgc ] | |
Y281 | * | Biomuta | DOID:3963 / thyroid carcinoma [ icgc ] | |
K297 | N297 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
Y340 | N340 | Biomuta | DOID:1324 / lung cancer [ tcga ] | |
R380 | H380 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
T399 | M399 | Biomuta | DOID:3070 / malignant glioma [ cosmic, icgc, tcga ] |