iPTMnet Report for Q3LXA3 (TKFC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q3LXA3 / TKFC_HUMAN
Protein Name Triokinase/FMN cyclase
Gene Name Name: TKFC
Synonyms:DAK;
Organism Homo sapiens (Human)

PRO ID PR:Q3LXA3
DAG View
PRO Name triokinase/FMN cyclase (human)
Definition A triokinase/FMN cyclase that is encoded in the genome of human.
Short Label hTKFC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q3LXA3 (TKFC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K46 Ubiquitination PhosphoSitePlus
R115 Methylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus   UniProt 24275569
S363 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
K372 Acetylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
C404 S-Nitrosylation dbSNO 19483679
K420 Ubiquitination PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus   UniProt 24275569
K522 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S350 Phosphorylation HPRD 20166139
S436 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R115 W115 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R115 Q115 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S371 * Biomuta DOID:363 / uterine cancer [ cosmic ]