iPTMnet Report for Q3B726 (POLR1F)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q3B726 / RPA43_HUMAN
Protein Name DNA-directed RNA polymerase I subunit RPA43
Gene Name Name: POLR1F
Synonyms:TWISTNB;
Organism Homo sapiens (Human)

PRO ID PR:Q3B726
DAG View
PRO Name DNA-directed RNA polymerase I subunit RPA43 (human)
Definition A DNA-directed RNA polymerase I subunit RPA43 that is encoded in the genome of human.
Short Label hPOLR1F
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q3B726 (POLR1F) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S60 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231, 18212344
C193 Methylation IEDB 31844290
T215 Phosphorylation PhosphoSitePlus
Y238 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus   UniProt 23186163
T254 Phosphorylation PhosphoSitePlus
S297 Phosphorylation HPRD   PhosphoSitePlus 17081983
S299 Phosphorylation PhosphoSitePlus
S300 Phosphorylation HPRD   PhosphoSitePlus 17081983
Y302 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S304 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18452278, 18669648, 20068231
S316 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18767875, 18452278, 19651622, 18669648, 20068231
T322 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18767875, 23186163
S328 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18452278, ...18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 * Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S60 L60 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S242 I242 Biomuta DOID:1324 / lung cancer [ cosmic ]
S299 F299 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S300 R300 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S316 T316 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S328 T328 Biomuta DOID:3571 / liver cancer [ cosmic ]