Protein Information

Cytoscape View


UniProt AC / UniProt ID Q38SD2 / LRRK1_HUMAN
Protein Name Leucine-rich repeat serine/threonine-protein kinase 1
Gene Name Name: LRRK1
Synonyms:KIAA1790;
Organism Homo sapiens (Human)

PRO ID PR:Q38SD2
DAG View
PRO Name leucine-rich repeat serine/threonine-protein kinase 1 (human)
Definition A leucine-rich repeat serine/threonine-protein kinase 1 that is encoded in the genome of human.
Short Label hLRRK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q38SD2 (LRRK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T30 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
Y971 Phosphorylation neXtProt   PhosphoSitePlus 22337768
Y971 Phosphorylation P00533 (EGFR) neXtProt   PhosphoSitePlus 22337768
K1054 Methylation PhosphoSitePlus
Y1063 Phosphorylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
Y1098 Phosphorylation PhosphoSitePlus
S1100 Phosphorylation PhosphoSitePlus
S1103 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
S1241 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation PhosphoSitePlus
K1276 Acetylation PhosphoSitePlus
K1278 Acetylation PhosphoSitePlus
T1295 Phosphorylation PhosphoSitePlus
S1302 Phosphorylation PhosphoSitePlus
T1427 Phosphorylation PhosphoSitePlus 26192437
T1427 Phosphorylation P06493 (CDK1) PhosphoSitePlus 26192437
Y1430 Phosphorylation PhosphoSitePlus
T1628 Phosphorylation PhosphoSitePlus
K1678 Ubiquitination PhosphoSitePlus
S1817 Phosphorylation PhosphoSitePlus 26192437
S1817 Phosphorylation P53350 (PLK1) PhosphoSitePlus 26192437
S1855 Phosphorylation PhosphoSitePlus
S1858 Phosphorylation PhosphoSitePlus


Q38SD2 (LRRK1) as PTM Enzyme



Substrate Site Score Source PMID
Q96SN8 (CDK5RAP2) T102 PhosphoSitePlus 26192437
Q96SN8 (CDK5RAP2) S140 PhosphoSitePlus 26192437


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T175 M175 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, tcga ] DOID:3070 / malignant glioma [ cosmic ]
S360 L360 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S405 Y405 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K453 N453 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K1278 R1278 Biomuta DOID:1324 / lung cancer [ tcga ]
S1858 N1858 Biomuta DOID:1324 / lung cancer [ icgc ]