Protein Information

Cytoscape View

UniProt AC / UniProt ID Q32P41 / TRM5_HUMAN
Protein Name tRNA (guanine(37)-N1)-methyltransferase
Gene Name Name: TRMT5
Organism Homo sapiens (Human)

DAG View
PRO Name tRNA (guanine(37)-N1)-methyltransferase (human)
Definition A tRNA (guanine-N(1)-)-methyltransferase that is encoded in the genome of human.
Short Label hTRMT5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q32P41 (TRMT5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
K84 Sumoylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K344 Acetylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K357 Sumoylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
K502 Sumoylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K84 N84 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K229 R229 Biomuta DOID:1612 / breast cancer [ tcga ]
K264 N264 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
Y272 C272 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K334 Q334 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K357 Q357 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S499 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]