iPTMnet Report for Q32MZ4 (LRRFIP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q32MZ4 / LRRF1_HUMAN
Protein Name Leucine-rich repeat flightless-interacting protein 1
Gene Name Name: LRRFIP1
Synonyms:GCF2,TRIP;
Organism Homo sapiens (Human)

PRO ID PR:Q32MZ4
DAG View
PRO Name leucine-rich repeat flightless-interacting protein 1 (human)
Definition A leucine-rich repeat flightless-interacting protein 1 that is encoded in the genome of human.
Short Label hLRRFIP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q32MZ4 (LRRFIP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330, 20068231
S3 Phosphorylation PhosphoSitePlus
C14 Methylation IEDB 31844290
S16 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...20068231
K21 Ubiquitination PhosphoSitePlus
T65 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
T114 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S115 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S116 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S120 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 20068231
T123 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S124 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S126 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T129 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K185 Methylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
T295 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S300 Phosphorylation PhosphoSitePlus
K305 Sumoylation PhosphoSitePlus
K314 Acetylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
T403 Phosphorylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
T477 O-Glycosylation GlyGen 23301498, 30379171, 26853435, ...29351928, 35132862, 28510447
S521 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S555 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S564 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
K568 Acetylation PhosphoSitePlus
K570 Acetylation PhosphoSitePlus
S581 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T587 Phosphorylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
T600 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
S618 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S638 Phosphorylation PhosphoSitePlus
C644 S-Nitrosylation dbSNO 26338901
K649 Ubiquitination PhosphoSitePlus
T676 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S687 Phosphorylation phospho.ELM 18669648
T711 Phosphorylation PhosphoSitePlus
S713 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S714 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163, ...20068231
S720 Phosphorylation PhosphoSitePlus
R725 Methylation PhosphoSitePlus
S733 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S735 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S739 Phosphorylation PhosphoSitePlus
C750 S-Nitrosylation dbSNO 26338901
S753 Phosphorylation PhosphoSitePlus
K762 Ubiquitination PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S768 Phosphorylation PhosphoSitePlus   UniProt 23186163
S775 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation HPRD 20068231
S3 Phosphorylation HPRD 20068231
S16 Phosphorylation HPRD 17322306, 18669648, 19415658, ...20068231
T114 Phosphorylation HPRD 18669648, 20058876
S115 Phosphorylation HPRD 18669648, 20068231
S116 Phosphorylation HPRD 18669648, 20058876, 20068231
S120 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19664994, 20068231
T123 Phosphorylation HPRD 18669648
S124 Phosphorylation HPRD 18669648, 20068231
S126 Phosphorylation HPRD 18669648
K137 Ubiquitination PhosphoSitePlus
T271 Phosphorylation HPRD 17287340
S497 Phosphorylation HPRD 15302935
S531 Phosphorylation HPRD 19651622, 19664994, 20068231
S540 Phosphorylation HPRD 20068231
S541 Phosphorylation HPRD 19651622, 20068231
S557 Phosphorylation HPRD 19651622, 18669648, 20068231
T563 Phosphorylation HPRD 18212344
S594 Phosphorylation HPRD 18669648
S614 Phosphorylation HPRD 19413330
T652 Phosphorylation HPRD 19413330, 18669648
S663 Phosphorylation HPRD 18669648
T687 Phosphorylation HPRD 19413330, 19651622
S689 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995, 20068231
S690 Phosphorylation HPRD 19413330, 18691976, 18212344, ...19664994, 19664995, 19651622, 17322306, 18669648, 19415658, 20068231
S709 Phosphorylation HPRD 17322306, 18669648, 20068231
S711 Phosphorylation HPRD 18669648
S742 Phosphorylation HPRD 20068231
S744 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S88 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T20 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K21 R21 Biomuta DOID:363 / uterine cancer [ icgc ]
S66 L66 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S68 C68 Biomuta DOID:1612 / breast cancer [ cosmic ]
S90 F90 Biomuta DOID:1324 / lung cancer [ cosmic ]
S98 L98 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K105 E105 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S115 F115 Biomuta DOID:4159 / skin cancer [ cosmic ]
T123 A123 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S124 Y124 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T129 I129 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K137 E137 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K173 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S209 N209 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S228 N228 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]
T271 A271 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K289 E289 Biomuta DOID:363 / uterine cancer [ icgc ]
S290 L290 Biomuta DOID:363 / uterine cancer [ icgc ]
T295 A295 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S300 T300 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S467 G467 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S540 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S557 F557 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S559 Y559 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S559 C559 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T563 A563 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
S564 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K570 N570 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S581 F581 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T587 A587 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
T596 M596 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S603 I603 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T652 A652 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T676 A676 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T687 A687 Biomuta DOID:3571 / liver cancer [ cosmic ]
T711 A711 Biomuta DOID:3571 / liver cancer [ cosmic ]
R725 C725 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
S744 G744 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S768 G768 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]