iPTMnet Report for Q2Y0W8 (SLC4A8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q2Y0W8 / S4A8_HUMAN
Protein Name Electroneutral sodium bicarbonate exchanger 1
Gene Name Name: SLC4A8
Synonyms:KIAA0739,NBC;
Organism Homo sapiens (Human)

PRO ID PR:Q2Y0W8
DAG View
PRO Name electroneutral sodium bicarbonate exchanger 1 (human)
Definition An electroneutral sodium bicarbonate exchanger 1 that is encoded in the genome of human.
Short Label hSLC4A8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q2Y0W8 (SLC4A8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y49 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
T717 Phosphorylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
K1012 Ubiquitination PhosphoSitePlus
K1039 Acetylation PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
S1056 Phosphorylation PhosphoSitePlus
S1067 Phosphorylation PhosphoSitePlus
S1080 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S237 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y49 H49 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y49 C49 Biomuta DOID:3571 / liver cancer [ cosmic ]
T160 S160 Biomuta DOID:3571 / liver cancer [ cosmic ]
S237 F237 Biomuta DOID:4159 / skin cancer [ cosmic ]
T717 M717 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
T717 R717 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]