Protein Information

Cytoscape View

UniProt AC / UniProt ID Q2NL82 / TSR1_HUMAN
Protein Name Pre-rRNA-processing protein TSR1 homolog
Gene Name Name: TSR1
Organism Homo sapiens (Human)

DAG View
PRO Name pre-rRNA-processing protein TSR1 homolog (human)
Definition A pre-rRNA-processing protein TSR1 that is encoded in the genome of human.
Short Label hTSR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q2NL82 (TSR1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R24 Methylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K42 Methylation PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
R279 Methylation PhosphoSitePlus
K346 Sumoylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
Y459 Phosphorylation PhosphoSitePlus
K470 Sumoylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
Y475 Phosphorylation HPRD   PhosphoSitePlus 17081983
K476 Sumoylation PhosphoSitePlus
T490 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K502 Acetylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
T534 Phosphorylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
T577 Phosphorylation PhosphoSitePlus
T605 Phosphorylation HPRD   PhosphoSitePlus 20068231
S626 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
T633 Phosphorylation PhosphoSitePlus
K709 Ubiquitination PhosphoSitePlus
K742 Acetylation PhosphoSitePlus
K752 Acetylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
K760 Sumoylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
K776 Sumoylation PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
K791 Sumoylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K32 N32 Biomuta DOID:363 / uterine cancer [ tcga ]
R279 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K384 N384 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S386 G386 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S512 Y512 Biomuta DOID:363 / uterine cancer [ tcga ]
T605 P605 Biomuta DOID:1612 / breast cancer [ cosmic ]
T633 S633 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K742 N742 Biomuta DOID:363 / uterine cancer [ tcga ]