iPTMnet Report for Q2NKX8 (ERCC6L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q2NKX8 / ERC6L_HUMAN
Protein Name DNA excision repair protein ERCC-6-like
Gene Name Name: ERCC6L
Synonyms:PICH;
Organism Homo sapiens (Human)

PRO ID PR:Q2NKX8
DAG View
PRO Name DNA excision repair protein ERCC-6-like (human)
Definition A DNA excision repair protein ERCC-6-like that is encoded in the genome of human.
Short Label hERCC6L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q2NKX8 (ERCC6L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
K33 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K48 Methylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K55 Methylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
Y618 Phosphorylation PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
Y696 Phosphorylation PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
S755 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
S759 Phosphorylation PhosphoSitePlus
T760 Phosphorylation HPRD   PhosphoSitePlus 18691976
T763 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
S774 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...19691289
S790 Phosphorylation PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
T797 Phosphorylation PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
T805 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S807 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19691289, ...18669648, 20068231
S810 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 18669648, 19691289, ...20068231
T813 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
K816 Ubiquitination PhosphoSitePlus
S820 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18691976, 18669648
T826 Phosphorylation HPRD   PhosphoSitePlus 18691976
S828 Phosphorylation HPRD   PhosphoSitePlus 18691976
S829 Phosphorylation HPRD   PhosphoSitePlus 18691976
S835 Phosphorylation PhosphoSitePlus
T838 Phosphorylation PhosphoSitePlus
T847 Phosphorylation PhosphoSitePlus
K853 Ubiquitination PhosphoSitePlus
S864 Phosphorylation HPRD   PhosphoSitePlus 18669648
Y867 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
K871 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K885 Ubiquitination PhosphoSitePlus
S968 Phosphorylation HPRD   PhosphoSitePlus 18691976
S969 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S971 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
K977 Ubiquitination PhosphoSitePlus
S980 Phosphorylation HPRD   PhosphoSitePlus 18691976
S984 Phosphorylation HPRD   PhosphoSitePlus 18691976
S988 Phosphorylation PhosphoSitePlus
S995 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
T997 Phosphorylation PhosphoSitePlus
S1000 Phosphorylation HPRD   PhosphoSitePlus 18691976
S1004 Phosphorylation HPRD   PhosphoSitePlus 18691976
K1016 Ubiquitination PhosphoSitePlus
S1028 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18691976, 19664994, 18452278, 19651622, 18669648, 19690332, 20068231
S1036 Phosphorylation HPRD   PhosphoSitePlus 18691976
K1038 Ubiquitination PhosphoSitePlus
T1040 Phosphorylation HPRD   PhosphoSitePlus 18691976
S1041 Phosphorylation HPRD   PhosphoSitePlus 18691976
S1042 Phosphorylation HPRD   PhosphoSitePlus 18691976
S1062 Phosphorylation HPRD   PhosphoSitePlus 18691976
T1063 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 17218258
T1063 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 17218258
T1063 Phosphorylation P53350 (PLK1) PhosphoSitePlus 17218258
K1065 Ubiquitination PhosphoSitePlus
S1069 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18691976, 19691289, 18669648, 20068231
S1076 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1077 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1081 Phosphorylation PhosphoSitePlus
S1082 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1085 Ubiquitination PhosphoSitePlus
S1086 Phosphorylation PhosphoSitePlus
S1089 Phosphorylation PhosphoSitePlus
S1098 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19690332
S1117 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation HPRD   PhosphoSitePlus 19413330
S1152 Phosphorylation PhosphoSitePlus
S1153 Phosphorylation HPRD   PhosphoSitePlus 19413330
K1156 Methylation PhosphoSitePlus
S1158 Phosphorylation PhosphoSitePlus
T1172 Phosphorylation HPRD 18691976
S1181 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
S1188 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18691976, 20068231
Y1200 Phosphorylation PhosphoSitePlus
K1205 Ubiquitination PhosphoSitePlus
K1225 Ubiquitination PhosphoSitePlus
S1242 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K116 N116 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S180 N180 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K312 E312 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K348 N348 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, tcga ]
S399 L399 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K408 N408 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S738 F738 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S738 Y738 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K749 R749 Biomuta DOID:4159 / skin cancer [ cosmic ]
T763 A763 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T826 I826 Biomuta DOID:1319 / brain cancer [ icgc ]
S828 F828 Biomuta DOID:1612 / breast cancer [ icgc ]
S835 T835 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K885 Q885 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S969 N969 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S988 C988 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1042 N1042 Biomuta [ cosmic ]
S1077 T1077 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1081 T1081 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K1085 T1085 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1086 Y1086 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1089 Y1089 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1089 F1089 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1135 N1135 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1242 T1242 Biomuta DOID:5041 / esophageal cancer [ cosmic ]