iPTMnet Report for Q2M296 (MTHFSD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q2M296 / MTHSD_HUMAN
Protein Name Methenyltetrahydrofolate synthase domain-containing protein
Gene Name Name: MTHFSD
Organism Homo sapiens (Human)

PRO ID PR:Q2M296
DAG View
PRO Name methenyltetrahydrofolate synthase domain-containing protein (human)
Definition A methenyltetrahydrofolate synthase domain-containing protein that is encoded in the genome of human.
Short Label hMTHFSD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q2M296 (MTHFSD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K41 Methylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K41 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K63 N63 Biomuta DOID:263 / kidney cancer [ cosmic ]
T83 K83 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S296 C296 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]