iPTMnet Report for Q17RS7 (GEN1)
Protein Information
| UniProt AC / UniProt ID | Q17RS7 / GEN_HUMAN |
| Protein Name | Flap endonuclease GEN homolog 1 |
| Gene Name | Name: GEN1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q17RS7 |
| PRO Name | flap endonuclease GEN homolog 1 (human) |
| Definition | A flap endonuclease GEN homolog 1 that is encoded in the genome of human. |
| Short Label | hGEN1 |
| Category | organism-gene |
Q17RS7 (GEN1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K14 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K43 | Acetylation | score1 | PhosphoSitePlus | |||
| S47 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K88 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K99 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K104 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K111 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K175 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K188 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K190 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K219 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K224 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K230 | Acetylation | score1 | PhosphoSitePlus | |||
| K230 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K257 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S269 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y292 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T380 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 26682650 | ||
| Y382 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T438 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 26682650 | ||
| K557 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K611 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K644 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K645 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K675 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K681 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K696 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T697 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K704 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S717 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K721 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K739 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K749 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S753 | O-Glycosylation | score1 | GlyGen | 30379171, 35254053 | ||
| S757 | O-Glycosylation | score1 | GlyGen | 30379171, 35254053 | ||
| S759 | O-Glycosylation | score1 | GlyGen | 30379171, 35254053 | ||
| K764 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K780 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T785 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T786 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S794 | O-Glycosylation | score1 | GlyGen | 30379171, 35254053 | ||
| S801 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S802 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K812 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S842 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K872 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K882 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S893 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K43 | E43 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K88 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y292 | C292 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K611 | N611 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| T697 | A697 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K704 | N704 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K721 | N721 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K749 | R749 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S753 | Y753 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S757 | Y757 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S794 | N794 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| S794 | T794 | Biomuta | DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| S802 | C802 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
| S842 | N842 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S842 | I842 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S893 | N893 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
DAG View